High glucose and interleukin 1ß-induced apoptosis in human umbilical vein endothelial cells involves in down-regulation of monocarboxylate transporter 4.

Wang, Dong; Wang, Qingjie; Yan, Gaoliang; Qiao, Yong; Sun, Ling; Zhu, Boqian; Tang, Chengchun; Gu, Yuchun

Wang, Dong; Wang, Qingjie; Yan, Gaoliang; Qiao, Yong; Sun, Ling; Zhu, Boqian; Tang, Chengchun; Gu, Yuchun.

Afiliação

Wang D; Department of Cardiology, Zhongda Hospital of Southeast University Medical School, Dingjiaqiao Road, 210009, Nanjing, Jiangsu, China.
Wang Q; Department of Cardiology, Zhongda Hospital of Southeast University Medical School, Dingjiaqiao Road, 210009, Nanjing, Jiangsu, China.
Yan G; Department of Cardiology, Zhongda Hospital of Southeast University Medical School, Dingjiaqiao Road, 210009, Nanjing, Jiangsu, China.
Qiao Y; Department of Cardiology, Zhongda Hospital of Southeast University Medical School, Dingjiaqiao Road, 210009, Nanjing, Jiangsu, China.
Sun L; Department of Cardiology, Changzhou Hospital of Nanjing Medical University, Gehu Road, 213004, Changzhou, Jiangsu, China.
Zhu B; Department of Cardiology, Zhongda Hospital of Southeast University Medical School, Dingjiaqiao Road, 210009, Nanjing, Jiangsu, China.
Tang C; Department of Cardiology, Zhongda Hospital of Southeast University Medical School, Dingjiaqiao Road, 210009, Nanjing, Jiangsu, China. Electronic address: tangchengchun@medmail.com.cn.
Gu Y; Institute of Molecular Medicine, Peking University, Yiheyuan Road, 100871, Beijing, China. Electronic address: ycgu@pku.edu.cn.

Biochem Biophys Res Commun ; 466(4): 607-14, 2015 Oct 30.

Article em En | MEDLINE | ID: mdl-26363456

Assuntos

Apoptose/fisiologia; Glucose/metabolismo; Interleucina-1beta/metabolismo; Transportadores de Ácidos Monocarboxílicos/metabolismo; Proteínas Musculares/metabolismo; Animais; Apoptose/genética; Angiopatias Diabéticas/etiologia; Angiopatias Diabéticas/metabolismo; Angiopatias Diabéticas/patologia; Regulação para Baixo; Endotélio Vascular/metabolismo; Endotélio Vascular/patologia; Técnicas de Silenciamento de Genes; Células Endoteliais da Veia Umbilical Humana; Humanos; Concentração de Íons de Hidrogênio; Ácido Láctico/metabolismo; Masculino; Camundongos; Camundongos Endogâmicos C57BL; Camundongos Mutantes; Transportadores de Ácidos Monocarboxílicos/antagonistas & inibidores; Transportadores de Ácidos Monocarboxílicos/genética; Proteínas Musculares/antagonistas & inibidores; Proteínas Musculares/genética; RNA Mensageiro/genética; RNA Mensageiro/metabolismo; Receptores para Leptina/genética

Palavras-chave

Endothelial cells; Endothelium damage; Lactate; Monocarboxylate transporter 4; Scanning ion conductance microscopy

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Apoptose / Transportadores de Ácidos Monocarboxílicos / Interleucina-1beta / Glucose / Proteínas Musculares Tipo de estudo: Etiology_studies Limite: Animals / Humans / Male Idioma: En Revista: Biochem Biophys Res Commun Ano de publicação: 2015 Tipo de documento: Article País de afiliação: China

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