Canonical transient receptor potential 3 channels activate NF-&#954;B to mediate allergic airway disease via PKC-&#945;/I&#954;B-&#945; and calcineurin/I&#954;B-ß pathways.

Song, Tengyao; Zheng, Yun-Min; Vincent, Peter A; Cai, Dongsheng; Rosenberg, Paul; Wang, Yong-Xiao

Canonical transient receptor potential 3 channels activate NF-κB to mediate allergic airway disease via PKC-α/IκB-α and calcineurin/IκB-ß pathways.

Song, Tengyao; Zheng, Yun-Min; Vincent, Peter A; Cai, Dongsheng; Rosenberg, Paul; Wang, Yong-Xiao.

Afiliação

Song T; *Center for Cardiovascular Sciences, Albany Medical College, Albany, New York, USA; Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, New York, USA; and Department of Medicine, Duke University School of Medicine, Durham, North Carolina, USA.
Zheng YM; *Center for Cardiovascular Sciences, Albany Medical College, Albany, New York, USA; Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, New York, USA; and Department of Medicine, Duke University School of Medicine, Durham, North Carolina, USA.
Vincent PA; *Center for Cardiovascular Sciences, Albany Medical College, Albany, New York, USA; Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, New York, USA; and Department of Medicine, Duke University School of Medicine, Durham, North Carolina, USA.
Cai D; *Center for Cardiovascular Sciences, Albany Medical College, Albany, New York, USA; Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, New York, USA; and Department of Medicine, Duke University School of Medicine, Durham, North Carolina, USA.
Rosenberg P; *Center for Cardiovascular Sciences, Albany Medical College, Albany, New York, USA; Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, New York, USA; and Department of Medicine, Duke University School of Medicine, Durham, North Carolina, USA.
Wang YX; *Center for Cardiovascular Sciences, Albany Medical College, Albany, New York, USA; Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, New York, USA; and Department of Medicine, Duke University School of Medicine, Durham, North Carolina, USA wangy@mail.amc.edu.

FASEB J ; 30(1): 214-29, 2016 Jan.

Article em En | MEDLINE | ID: mdl-26373801

Assuntos

NF-kappa B/metabolismo; Hipersensibilidade Respiratória/metabolismo; Canais de Cátion TRPC/genética; Potenciais de Ação; Animais; Calcineurina/metabolismo; Sinalização do Cálcio; Proliferação de Células; Células Cultivadas; Terapia Genética; Quinase I-kappa B/metabolismo; Proteínas I-kappa B/metabolismo; Camundongos; Miócitos de Músculo Liso/efeitos dos fármacos; Miócitos de Músculo Liso/metabolismo; Inibidor de NF-kappaB alfa; NF-kappa B/genética; Proteína Quinase C/metabolismo; Pirazóis/farmacologia; Pirazóis/uso terapêutico; Hipersensibilidade Respiratória/tratamento farmacológico; Hipersensibilidade Respiratória/terapia; Sistemas do Segundo Mensageiro; Canais de Cátion TRPC/antagonistas & inibidores; Canais de Cátion TRPC/metabolismo

Palavras-chave

AIAD; ion channel; signaling pathway

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Hipersensibilidade Respiratória / NF-kappa B / Canais de Cátion TRPC Limite: Animals Idioma: En Revista: FASEB J Assunto da revista: BIOLOGIA / FISIOLOGIA Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Estados Unidos

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