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Repetitive transcranial magnetic stimulation in patients with drug-resistant major depression: A six-month clinical follow-up study.
Concerto, Carmen; Lanza, Giuseppe; Cantone, Mariagiovanna; Ferri, Raffaele; Pennisi, Giovanni; Bella, Rita; Aguglia, Eugenio.
Afiliação
  • Concerto C; a Department of Clinical and Experimental Medicine , Psychiatry Unit, University of Catania , Via Santa Sofia, Catania , Italy.
  • Lanza G; a Department of Clinical and Experimental Medicine , Psychiatry Unit, University of Catania , Via Santa Sofia, Catania , Italy.
  • Cantone M; b Department of Neurology I.C. , "Oasi" Institute for Research on Mental Retardation and Brain Aging (I.R.C.C.S.) . Via Conte Ruggero, Troina (EN) , Italy.
  • Ferri R; b Department of Neurology I.C. , "Oasi" Institute for Research on Mental Retardation and Brain Aging (I.R.C.C.S.) . Via Conte Ruggero, Troina (EN) , Italy.
  • Pennisi G; c Department "Specialità Medico-Chirurgiche" , University of Catania , Via Santa Sofia, Catania , Italy.
  • Bella R; d Department of Medical and Surgical Sciences and Advanced Technologies , Section of Neurosciences , Via Santa Sofia, Catania , Italy.
  • Aguglia E; a Department of Clinical and Experimental Medicine , Psychiatry Unit, University of Catania , Via Santa Sofia, Catania , Italy.
Int J Psychiatry Clin Pract ; 19(4): 252-8, 2015.
Article em En | MEDLINE | ID: mdl-26398527
OBJECTIVE: In this study we aimed to assess the long-term efficacy of repetitive Transcranial Magnetic Stimulation (rTMS) on depressive symptoms and cognitive performance in patients with drug-resistant major depressive disorder (MDD). METHODS: Fifteen drug-resistant depressed outpatients completed an acute trial with augmentative high-frequency rTMS over the left dorsolateral prefrontal cortex (DLPFC) and were compared with 15 drug-resistant MDD patients who underwent sham procedure. Depressive symptoms were evaluated with the Hamilton Depression Rating Scale and Montgomery-Asberg Depression Rating Scale. The Frontal Assessment Battery and the Stroop Color-Word Test Interference (Stroop T) were used to probe executive functions. Outcome measures were obtained at baseline, 4 weeks after the rTMS, as well as 3 months and 6 months after the end of the stimulation protocol. RESULTS: After the active rTMS, patients showed a significant decrease in the scores at the depression rating scales that lasted for 6 months. A transient improvement was also observed at the Stroop T, although it did not persist in time. CONCLUSIONS: High-frequency rTMS over the left DLPFC may have long-term antidepressant effect in drug-resistant MDD. TMS is a valuable tool for the add-on treatment of mood disorders and for the design of customized stimulation protocols.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Avaliação de Resultados em Cuidados de Saúde / Córtex Pré-Frontal / Transtorno Depressivo Maior / Estimulação Magnética Transcraniana / Função Executiva / Transtorno Depressivo Resistente a Tratamento Tipo de estudo: Guideline / Observational_studies / Prognostic_studies Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Int J Psychiatry Clin Pract Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Itália

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Avaliação de Resultados em Cuidados de Saúde / Córtex Pré-Frontal / Transtorno Depressivo Maior / Estimulação Magnética Transcraniana / Função Executiva / Transtorno Depressivo Resistente a Tratamento Tipo de estudo: Guideline / Observational_studies / Prognostic_studies Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Int J Psychiatry Clin Pract Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Itália