Docosahexaenoic Acid Attenuated Experimental Chronic Colitis in Interleukin 10-Deficient Mice by Enhancing Autophagy Through Inhibition of the mTOR Pathway.

Zhao, Jie; Dong, Jian-Ning; Wang, Hong-Gang; Zhao, Mingli; Sun, Jing; Zhu, Wei-Ming; Zuo, Lu-Gen; Gong, Jian-Feng; Li, Yi; Gu, Li-Li; Li, Ning; Li, Jie-Shou

Zhao, Jie; Dong, Jian-Ning; Wang, Hong-Gang; Zhao, Mingli; Sun, Jing; Zhu, Wei-Ming; Zuo, Lu-Gen; Gong, Jian-Feng; Li, Yi; Gu, Li-Li; Li, Ning; Li, Jie-Shou.

Afiliação

Zhao J; 1 Department of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing, China.
Dong JN; 1 Department of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing, China.
Wang HG; 1 Department of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing, China.
Zhao M; 1 Department of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing, China.
Sun J; 1 Department of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing, China.
Zhu WM; 1 Department of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing, China.
Zuo LG; 1 Department of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing, China.
Gong JF; 1 Department of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing, China.
Li Y; 1 Department of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing, China.
Gu LL; 1 Department of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing, China.
Li N; 1 Department of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing, China.
Li JS; 1 Department of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing, China.

JPEN J Parenter Enteral Nutr ; 41(5): 824-829, 2017 07.

Article em En | MEDLINE | ID: mdl-26407598

Assuntos

Autofagia/efeitos dos fármacos; Colite/tratamento farmacológico; Ácidos Docosa-Hexaenoicos/farmacologia; Interleucina-10/deficiência; Serina-Treonina Quinases TOR/genética; Animais; Doença Crônica; Colo/efeitos dos fármacos; Colo/metabolismo; Modelos Animais de Doenças; Interferon gama/genética; Interferon gama/metabolismo; Interleucina-10/sangue; Camundongos; Camundongos Endogâmicos C57BL; Camundongos Knockout; Fosfatidilinositol 3-Quinases/genética; Fosfatidilinositol 3-Quinases/metabolismo; Proteínas Proto-Oncogênicas c-akt/genética; Proteínas Proto-Oncogênicas c-akt/metabolismo; Transdução de Sinais; Serina-Treonina Quinases TOR/antagonistas & inibidores; Serina-Treonina Quinases TOR/sangue; Fator de Necrose Tumoral alfa/genética; Fator de Necrose Tumoral alfa/metabolismo

Palavras-chave

Crohn's disease; autophagy; docosahexaenoic acid; interleukin 10deficient mice; mTOR pathway

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Autofagia / Ácidos Docosa-Hexaenoicos / Interleucina-10 / Colite / Serina-Treonina Quinases TOR Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: JPEN J Parenter Enteral Nutr Ano de publicação: 2017 Tipo de documento: Article País de afiliação: China

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