PHEA-PLA biocompatible nanoparticles by technique of solvent evaporation from multiple emulsions.
Int J Pharm
; 495(2): 719-27, 2015 Nov 30.
Article
em En
| MEDLINE
| ID: mdl-26410757
ABSTRACT
Nanocarriers of amphiphilic polymeric materials represent versatile delivery systems for poorly water soluble drugs. In this work the technique of solvent evaporation from multiple emulsions was applied to produce nanovectors based on new amphiphilic copolymer, the α,ß-poly(N-2-hydroxyethyl)-DL-aspartamide-polylactic acid (PHEA-PLA), purposely synthesized to be used in the controlled release of active molecules poorly soluble in water. To this aim an amphiphilic derivative of PHEA, a hydrophilic polymer, was synthesized by derivatization of the polymeric backbone with hydrophobic grafts of polylactic acid (PLA). The achieved copolymer was thus used to produce nanoparticles loaded with α tocopherol (vitamin E) adopted as lipophilic model molecule. Applying a protocol based on solvent evaporation from multiple emulsions assisted by ultrasonic energy and optimizing the emulsification process (solvent selection/separation stages), PHEA-PLA nanostructured particles with total α tocopherol entrapment efficiency (100%), were obtained. The drug release is expected to take place in lower times with respect to PLA due to the presence of the hydrophilic PHEA, therefore the produced nanoparticles can be used for semi-long term release drug delivery systems.
Palavras-chave
1,1'-CarbonyldiimidazoleCDI: PubChem CID: 68263; Amphiphilic polymer; Biocompatible polymer; DiethylamineDEA: PubChem CID: 8021; Drug delivery; Emulsions; Ethanolamine: PubChem CID: 700; N,N'-dimethylformamideDMF: PubChem CID: 6228; Nanoparticles; PHEAPLA; Poly-lactic acidPLA: PubChem CID: 612; PolysuccinimidePSI: PubChem CID: 5960; Polyvinyl alcoholPVA: PubChem CID: 11199; Ultrasonic energy; α,ß-Poly(N-2-hydroxyethyl)-dl-aspartamidePHEA: PubChem CID: 155399; α-Tocopherol: PubChem CID: 14985
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Peptídeos
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Polímeros
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Sistemas de Liberação de Medicamentos
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Ácido Láctico
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Alfa-Tocoferol
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Nanopartículas
Idioma:
En
Revista:
Int J Pharm
Ano de publicação:
2015
Tipo de documento:
Article