Forsythoneosides A-D, Neuroprotective Phenethanoid and Flavone Glycoside Heterodimers from the Fruits of Forsythia suspensa.
J Nat Prod
; 78(10): 2390-7, 2015 Oct 23.
Article
em En
| MEDLINE
| ID: mdl-26422318
ABSTRACT
Forsythoneosides A-D (1-4), four unusual adducts of a flavonoid unit fused to a phenylethanoid glycoside through a pyran ring or carbon-carbon bond, and four new phenylethanoid glycosides (5-8) were isolated from the fruits of Forsythia suspensa, together with nine known compounds. The structures of 1-8, including their absolute configurations, were elucidated by spectroscopic data as well as experimental and calculated electronic circular dichroism analysis. Compounds 2 and 4 inhibited PC12 cell damage induced by rotenone, and increased cell viability from 53.9 ± 7.1% to 70.1 ± 4.0% and 67.9 ± 5.2% at 0.1 µM, respectively.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Medicamentos de Ervas Chinesas
/
Fármacos Neuroprotetores
/
Forsythia
/
Flavonas
/
Glicosídeos
Limite:
Animals
Idioma:
En
Revista:
J Nat Prod
Ano de publicação:
2015
Tipo de documento:
Article