Tauroursodeoxycholic Acid Protects Retinal Function and Structure in rd1 Mice.
Adv Exp Med Biol
; 854: 431-6, 2016.
Article
em En
| MEDLINE
| ID: mdl-26427442
ABSTRACT
We explored the potential protective effects of tauroursodeoxycholic acid (TUDCA) on cone photoreceptor survival in a model of rapid retinal degeneration, the ß-Pde6 (rd1) (rd1) mouse model. We injected two strains of rd1 mice (B6.C3-Pde6b (rd1) Hps4(le)/J and C57BL/6J-Pde6b (rd1-2)/J mice) daily from postnatal day (P) 6 to P21 with TUDCA or vehicle. At P21, retinal function was evaluated with light-adapted electroretinography (ERG) and retinal structure was observed with plastic or frozen sections. TUDCA treatment partially preserved function and structure in B6.C3-Pde6b (rd1) Hps4(le)/J mice but only partially preserved structure in C57BL/6J-Pde6b (rd1-2)/J mice. Our results suggest a possible intervention for patients undergoing rapid retinal degeneration.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Retina
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Ácido Tauroquenodesoxicólico
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Retinose Pigmentar
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Substâncias Protetoras
Limite:
Animals
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Humans
Idioma:
En
Revista:
Adv Exp Med Biol
Ano de publicação:
2016
Tipo de documento:
Article
País de afiliação:
Estados Unidos