Galactomannan Downregulates the Inflammation Responses in Human Macrophages via NFκB2/p100.
Mediators Inflamm
; 2015: 942517, 2015.
Article
em En
| MEDLINE
| ID: mdl-26441484
ABSTRACT
We show that galactomannan, a polysaccharide consisting of a mannose backbone with galactose side groups present on the cell wall of several fungi, induces a reprogramming of the inflammatory response in human macrophages through dectin-1 receptor. The nuclear factor kappa-light-chain-enhancer of activated B cells 2 (NFκB2)/p100 was overexpressed after galactomannan challenge. Knocking down NFκB2/p100 using small interfering RNA (siRNA) indicated that NFκB2/p100 expression is a crucial factor in the progression of the galactomannan-induced refractoriness. The data presented in this study could be used as a modulator of inflammatory response in clinical situations where refractory state is required.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Subunidade p52 de NF-kappa B
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Inflamação
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Macrófagos
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Mananas
Limite:
Humans
Idioma:
En
Revista:
Mediators Inflamm
Assunto da revista:
BIOQUIMICA
/
PATOLOGIA
Ano de publicação:
2015
Tipo de documento:
Article
País de afiliação:
Espanha