Cigarette Smoke Disrupted Lung Endothelial Barrier Integrity and Increased Susceptibility to Acute Lung Injury via Histone Deacetylase 6.

Borgas, Diana; Chambers, Eboni; Newton, Julie; Ko, Junsuk; Rivera, Stephanie; Rounds, Sharon; Lu, Qing

Borgas, Diana; Chambers, Eboni; Newton, Julie; Ko, Junsuk; Rivera, Stephanie; Rounds, Sharon; Lu, Qing.

Afiliação

Borgas D; Vascular Research Laboratory, Providence Veterans Affairs Medical Center, Department of Medicine, Alpert Medical School of Brown University, Providence, Rhode Island.
Chambers E; Vascular Research Laboratory, Providence Veterans Affairs Medical Center, Department of Medicine, Alpert Medical School of Brown University, Providence, Rhode Island.
Newton J; Vascular Research Laboratory, Providence Veterans Affairs Medical Center, Department of Medicine, Alpert Medical School of Brown University, Providence, Rhode Island.
Ko J; Vascular Research Laboratory, Providence Veterans Affairs Medical Center, Department of Medicine, Alpert Medical School of Brown University, Providence, Rhode Island.
Rivera S; Vascular Research Laboratory, Providence Veterans Affairs Medical Center, Department of Medicine, Alpert Medical School of Brown University, Providence, Rhode Island.
Rounds S; Vascular Research Laboratory, Providence Veterans Affairs Medical Center, Department of Medicine, Alpert Medical School of Brown University, Providence, Rhode Island.
Lu Q; Vascular Research Laboratory, Providence Veterans Affairs Medical Center, Department of Medicine, Alpert Medical School of Brown University, Providence, Rhode Island.

Am J Respir Cell Mol Biol ; 54(5): 683-96, 2016 05.

Article em En | MEDLINE | ID: mdl-26452072

Assuntos

Lesão Pulmonar Aguda/enzimologia; Lesão Pulmonar Aguda/patologia; Endotélio Vascular/patologia; Histona Desacetilases/metabolismo; Pulmão/patologia; Fumar/efeitos adversos; Lesão Pulmonar Aguda/microbiologia; Animais; Bovinos; Permeabilidade da Membrana Celular/efeitos dos fármacos; Suscetibilidade a Doenças; Células Endoteliais/efeitos dos fármacos; Células Endoteliais/enzimologia; Células Endoteliais/microbiologia; Células Endoteliais/patologia; Endotélio Vascular/enzimologia; Glicogênio Sintase Quinase 3 beta/metabolismo; Inibidores de Histona Desacetilases/farmacologia; Humanos; Lipopolissacarídeos/farmacologia; Masculino; Camundongos Endogâmicos C57BL; Microvasos/patologia; Estresse Oxidativo/efeitos dos fármacos; Fosforilação/efeitos dos fármacos; Proteínas Proto-Oncogênicas c-akt/metabolismo; Pseudomonas aeruginosa/efeitos dos fármacos; Pseudomonas aeruginosa/fisiologia

Palavras-chave

acute lung injury; cigarette smoke; endothelial cells; histone deacetylase 6; permeability

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Endotélio Vascular / Fumar / Lesão Pulmonar Aguda / Histona Desacetilases / Pulmão Limite: Animals / Humans / Male Idioma: En Revista: Am J Respir Cell Mol Biol Assunto da revista: BIOLOGIA MOLECULAR Ano de publicação: 2016 Tipo de documento: Article

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