Cell-autonomous requirement for TCF1 and LEF1 in the development of Natural Killer T cells.
Mol Immunol
; 68(2 Pt B): 484-9, 2015 Dec.
Article
em En
| MEDLINE
| ID: mdl-26490636
ABSTRACT
Natural killer T (NKT) cells develop from common CD4(+) CD8(+) thymocyte precursors. Transcriptional programs that regulate the development of NKT cells in the thymus development remain to be fully delineated. Here, we demonstrate a cell-intrinsic requirement for transcription factors TCF1 and LEF1 for the development of all subsets of NKT cells. Conditional deletion of TCF1 alone results in a substantial reduction in NKT cells. The remaining NKT cells are eliminated when TCF1 and LEF1 are both deleted. These data reveal an essential role for TCF1 and LEF1 in development of NKT cells.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Diferenciação Celular
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Fator 1-alfa Nuclear de Hepatócito
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Fator 1 de Ligação ao Facilitador Linfoide
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Células T Matadoras Naturais
Limite:
Animals
Idioma:
En
Revista:
Mol Immunol
Ano de publicação:
2015
Tipo de documento:
Article
País de afiliação:
Estados Unidos