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Expansion of CD25+ Innate Lymphoid Cells Reduces Atherosclerosis.
Engelbertsen, Daniel; Foks, Amanda C; Alberts-Grill, Noah; Kuperwaser, Felicia; Chen, Tao; Lederer, James A; Jarolim, Petr; Grabie, Nir; Lichtman, Andrew H.
Afiliação
  • Engelbertsen D; From the Departments of Pathology (D.E., A.C.F., N.A.-G., F.K., T.C., P.J., N.G., A.H.L.) and Surgery (J.A.L.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
  • Foks AC; From the Departments of Pathology (D.E., A.C.F., N.A.-G., F.K., T.C., P.J., N.G., A.H.L.) and Surgery (J.A.L.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
  • Alberts-Grill N; From the Departments of Pathology (D.E., A.C.F., N.A.-G., F.K., T.C., P.J., N.G., A.H.L.) and Surgery (J.A.L.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
  • Kuperwaser F; From the Departments of Pathology (D.E., A.C.F., N.A.-G., F.K., T.C., P.J., N.G., A.H.L.) and Surgery (J.A.L.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
  • Chen T; From the Departments of Pathology (D.E., A.C.F., N.A.-G., F.K., T.C., P.J., N.G., A.H.L.) and Surgery (J.A.L.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
  • Lederer JA; From the Departments of Pathology (D.E., A.C.F., N.A.-G., F.K., T.C., P.J., N.G., A.H.L.) and Surgery (J.A.L.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
  • Jarolim P; From the Departments of Pathology (D.E., A.C.F., N.A.-G., F.K., T.C., P.J., N.G., A.H.L.) and Surgery (J.A.L.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
  • Grabie N; From the Departments of Pathology (D.E., A.C.F., N.A.-G., F.K., T.C., P.J., N.G., A.H.L.) and Surgery (J.A.L.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
  • Lichtman AH; From the Departments of Pathology (D.E., A.C.F., N.A.-G., F.K., T.C., P.J., N.G., A.H.L.) and Surgery (J.A.L.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA. alichtman@partners.org.
Arterioscler Thromb Vasc Biol ; 35(12): 2526-35, 2015 Dec.
Article em En | MEDLINE | ID: mdl-26494229
OBJECTIVE: Innate lymphoid cells (ILCs) are a newly discovered subset of immune cells that promote tissue homeostasis and protect against pathogens. ILCs produce cytokines also produced by T lymphocytes that have been shown to affect atherosclerosis, but the influence of ILCs on atherosclerosis has not been explored. APPROACH AND RESULTS: We demonstrate that CD25(+) ILCs that produce type 2 cytokines (ILC2s) are present in the aorta of atherosclerotic immunodeficient ldlr(-/-)rag1(-/-) mice. To investigate the role of ILCs in atherosclerosis, ldlr(-/-)rag1(-/-) mice were concurrently fed an atherogenic diet and treated with either ILC-depleting anti-CD90.2 antibodies or IL-2/anti-IL-2 complexes that expand CD25(+) ILCs. Lesion development was not affected by anti-CD90.2 treatment, but was reduced in IL-2/anti-IL-2-treated mice. These IL-2-treated mice had reduced very low-density lipoprotein cholesterol and increased triglycerides compared with controls and reduced apolipoprotein B100 gene expression in the liver. IL-2/anti-IL-2 treatment caused expansion of ILC2s in aorta and other tissues, elevated levels of IL-5, systemic eosinophila, and hepatic eosinophilic inflammation. Blockade of IL-5 reversed the IL-2 complex-induced eosinophilia but did not change lesion size. CONCLUSIONS: This study demonstrates that expansion of CD25-expressing ILCs by IL-2/anti-IL-2 complexes leads to a reduction in very low-density lipoprotein cholesterol and atherosclerosis. Global depletion of ILCs by anti-CD90.2 did not significantly affect lesion size indicating that different ILC subsets may have divergent effects on atherosclerosis.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doenças da Aorta / Linfócitos / Interleucina-2 / Proliferação de Células / Aterosclerose / Subunidade alfa de Receptor de Interleucina-2 / Imunidade Inata / Anticorpos Tipo de estudo: Prognostic_studies Idioma: En Revista: Arterioscler Thromb Vasc Biol Assunto da revista: ANGIOLOGIA Ano de publicação: 2015 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doenças da Aorta / Linfócitos / Interleucina-2 / Proliferação de Células / Aterosclerose / Subunidade alfa de Receptor de Interleucina-2 / Imunidade Inata / Anticorpos Tipo de estudo: Prognostic_studies Idioma: En Revista: Arterioscler Thromb Vasc Biol Assunto da revista: ANGIOLOGIA Ano de publicação: 2015 Tipo de documento: Article