Androgen-primed castrate males are sufficient for methamphetamine-facilitated increases in proceptive behavior in female rats.
Horm Behav
; 78: 52-9, 2016 Feb.
Article
em En
| MEDLINE
| ID: mdl-26497407
ABSTRACT
Methamphetamine (MA) is a psychomotor stimulant associated with increases in sex drive in both men and women. Women, however, are far more likely to face social disadvantages as a consequence of MA use, and their increased sexual motivation poses additional health concerns such as unplanned pregnancies. To better understand the mechanisms underlying MA-facilitated sexual motivation in females, we previously established a rodent model where a "binge"-type administration paradigm of MA to sexually receptive female rats significantly increases proceptive behavior in the presence of a sexually active, gonadally-intact male. Our previous work with this model has led us to consider whether the increases in proceptive behavior are truly indicative of increased sexual motivation, or instead a consequence of heightened motor responsivity. Here, we test whether MA-induced increases in proceptive behaviors are specific to a sexually relevant stimulus. Females' sexual, social, exploratory behaviors, and interaction times were scored during the exposure to stimulus males, including castrates, and dihydrotestosterone (DHT)-treated castrates. MA-treated females demonstrated significant increases in proceptive behaviors toward DHT-treated castrate males but not toward castrate males. While the non-MA-treated females did display proceptive behavior, there was no significant difference between behaviors elicited by DHT-CX males compared to CX males. Our results support the hypothesis that MA facilitates proceptive behavior only in response to specific, androgen mediated sexually-relevant cues.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Comportamento Sexual Animal
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Di-Hidrotestosterona
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Estimulantes do Sistema Nervoso Central
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Androgênios
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Metanfetamina
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Motivação
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
Horm Behav
Ano de publicação:
2016
Tipo de documento:
Article
País de afiliação:
Estados Unidos