Aire Gets Company for Immune Tolerance.
Cell
; 163(4): 794-5, 2015 Nov 05.
Article
em En
| MEDLINE
| ID: mdl-26544932
ABSTRACT
A specialized subset of epithelial cells in the thymus "promiscuously" transcribes thousands of peripheral genes to ensure that developing T cells can test their antigen receptors for dangerous autoreactivity. New findings by Takaba et al. indicate that the transcription factor Fezf2 acts independently of Aire in thymic epithelial cells to generate "genetic noise" for immunological tolerance.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Timo
/
Proteínas de Ligação a DNA
/
Tolerância Imunológica
/
Proteínas do Tecido Nervoso
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Cell
Ano de publicação:
2015
Tipo de documento:
Article