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fosI Is a New Integron-Associated Gene Cassette Encoding Reduced Susceptibility to Fosfomycin.
Pelegrino, Karla de Oliveira; Campos, Juliana Coutinho; Sampaio, Suely Carlos Ferreira; Lezirovitz, Karina; Seco, Bruna Mara; Pereira, Mayne de Oliveira; Rocha, Darlan Augusto da Costa; Jové, Thomas; Nicodemo, Antonio Carlos; Sampaio, Jorge Luiz Mello.
Afiliação
  • Pelegrino Kde O; School of Medicine, Infectious Diseases Department, University of São Paulo, São Paulo, SP, Brazil.
  • Campos JC; Clinical Analysis and Toxicology Department, School of Pharmacy, University of São Paulo, São Paulo, SP, Brazil.
  • Sampaio SC; Departamento de Microbiologia e Imunologia, Universidade Federal de São Paulo, São Paulo, SP, Brazil.
  • Lezirovitz K; School of Medicine, Otorhinolaryngology Lab/LIM32, Hospital das Clínicas, University of São Paulo, São Paulo, SP, Brazil.
  • Seco BM; Clinical Analysis and Toxicology Department, School of Pharmacy, University of São Paulo, São Paulo, SP, Brazil.
  • Pereira Mde O; Clinical Analysis and Toxicology Department, School of Pharmacy, University of São Paulo, São Paulo, SP, Brazil.
  • Rocha DA; Clinical Analysis and Toxicology Department, School of Pharmacy, University of São Paulo, São Paulo, SP, Brazil.
  • Jové T; Université Limoges, INSERM, CHU Limoges, UMR_S 1092, Limoges, France.
  • Nicodemo AC; School of Medicine, Infectious Diseases Department, University of São Paulo, São Paulo, SP, Brazil.
  • Sampaio JL; Clinical Analysis and Toxicology Department, School of Pharmacy, University of São Paulo, São Paulo, SP, Brazil Fleury Medicine and Health, Microbiology Department, São Paulo, SP, Brazil sampaio@usp.br.
Antimicrob Agents Chemother ; 60(1): 686-8, 2016 01.
Article em En | MEDLINE | ID: mdl-26552984
ABSTRACT
In this work, we demonstrate that the fosI gene encodes a predicted small protein with 134 amino acids and determines reduced susceptibility to fosfomycin. It raised the MIC from 0.125 to 6 µg/ml when the pBRA100 plasmid was introduced into Escherichia coli TOP10 and to 16 µg/ml when the gene was cloned into the pBC_SK(-) vector and expressed in E. coli TOP10.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Farmacorresistência Bacteriana / Integrons / Escherichia coli / Fosfomicina / Antibacterianos Tipo de estudo: Risk_factors_studies Idioma: En Revista: Antimicrob Agents Chemother Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Brasil
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Farmacorresistência Bacteriana / Integrons / Escherichia coli / Fosfomicina / Antibacterianos Tipo de estudo: Risk_factors_studies Idioma: En Revista: Antimicrob Agents Chemother Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Brasil