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Extremely high genetic diversity in a single tumor points to prevalence of non-Darwinian cell evolution.
Ling, Shaoping; Hu, Zheng; Yang, Zuyu; Yang, Fang; Li, Yawei; Lin, Pei; Chen, Ke; Dong, Lili; Cao, Lihua; Tao, Yong; Hao, Lingtong; Chen, Qingjian; Gong, Qiang; Wu, Dafei; Li, Wenjie; Zhao, Wenming; Tian, Xiuyun; Hao, Chunyi; Hungate, Eric A; Catenacci, Daniel V T; Hudson, Richard R; Li, Wen-Hsiung; Lu, Xuemei; Wu, Chung-I.
Afiliação
  • Ling S; Key Laboratory of Genomics and Precision Medicine, China Gastrointestinal Cancer Research Center, Beijing Institute of Genomics, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Beijing 100101, People's Republic of China;
  • Hu Z; Key Laboratory of Genomics and Precision Medicine, China Gastrointestinal Cancer Research Center, Beijing Institute of Genomics, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Beijing 100101, People's Republic of China;
  • Yang Z; Key Laboratory of Genomics and Precision Medicine, China Gastrointestinal Cancer Research Center, Beijing Institute of Genomics, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Beijing 100101, People's Republic of China;
  • Yang F; Key Laboratory of Genomics and Precision Medicine, China Gastrointestinal Cancer Research Center, Beijing Institute of Genomics, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Beijing 100101, People's Republic of China;
  • Li Y; Key Laboratory of Genomics and Precision Medicine, China Gastrointestinal Cancer Research Center, Beijing Institute of Genomics, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Beijing 100101, People's Republic of China;
  • Lin P; State Key Laboratory of Biocontrol, College of Ecology and Evolution, Sun Yat-Sen University, Guangzhou 510275, People's Republic of China;
  • Chen K; Key Laboratory of Genomics and Precision Medicine, China Gastrointestinal Cancer Research Center, Beijing Institute of Genomics, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Beijing 100101, People's Republic of China;
  • Dong L; Key Laboratory of Genomics and Precision Medicine, China Gastrointestinal Cancer Research Center, Beijing Institute of Genomics, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Beijing 100101, People's Republic of China;
  • Cao L; Key Laboratory of Genomics and Precision Medicine, China Gastrointestinal Cancer Research Center, Beijing Institute of Genomics, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Beijing 100101, People's Republic of China;
  • Tao Y; Key Laboratory of Genomics and Precision Medicine, China Gastrointestinal Cancer Research Center, Beijing Institute of Genomics, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Beijing 100101, People's Republic of China;
  • Hao L; Key Laboratory of Genomics and Precision Medicine, China Gastrointestinal Cancer Research Center, Beijing Institute of Genomics, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Beijing 100101, People's Republic of China;
  • Chen Q; State Key Laboratory of Biocontrol, College of Ecology and Evolution, Sun Yat-Sen University, Guangzhou 510275, People's Republic of China;
  • Gong Q; Key Laboratory of Genomics and Precision Medicine, China Gastrointestinal Cancer Research Center, Beijing Institute of Genomics, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Beijing 100101, People's Republic of China;
  • Wu D; Key Laboratory of Genomics and Precision Medicine, China Gastrointestinal Cancer Research Center, Beijing Institute of Genomics, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Beijing 100101, People's Republic of China;
  • Li W; Key Laboratory of Genomics and Precision Medicine, China Gastrointestinal Cancer Research Center, Beijing Institute of Genomics, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Beijing 100101, People's Republic of China;
  • Zhao W; Key Laboratory of Genomics and Precision Medicine, China Gastrointestinal Cancer Research Center, Beijing Institute of Genomics, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Beijing 100101, People's Republic of China;
  • Tian X; Key Laboratory of Carcinogenesis and Translational Research, Peking University Cancer Hospital, Beijing 100142, People's Republic of China;
  • Hao C; Key Laboratory of Carcinogenesis and Translational Research, Peking University Cancer Hospital, Beijing 100142, People's Republic of China;
  • Hungate EA; Department of Pediatrics, University of Chicago, Chicago, IL 60637;
  • Catenacci DV; Department of Medicine, Section of Hematology/Oncology, University of Chicago, Chicago, IL 60637;
  • Hudson RR; Department of Ecology and Evolution, University of Chicago, Chicago, IL 60637;
  • Li WH; Biodiversity Research Center, Academia Sinica, Taipei 11529, Taiwan ciwu@uchicago.edu whli@gate.sinica.edu.tw luxm@big.ac.cn.
  • Lu X; Key Laboratory of Genomics and Precision Medicine, China Gastrointestinal Cancer Research Center, Beijing Institute of Genomics, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Beijing 100101, People's Republic of China; ciwu@uchicago.edu whli@gate.sinica.edu.tw luxm@big.ac.c
  • Wu CI; Key Laboratory of Genomics and Precision Medicine, China Gastrointestinal Cancer Research Center, Beijing Institute of Genomics, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Beijing 100101, People's Republic of China; State Key Laboratory of Biocontrol, College of Ecology
Proc Natl Acad Sci U S A ; 112(47): E6496-505, 2015 Nov 24.
Article em En | MEDLINE | ID: mdl-26561581
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Seleção Genética / Variação Genética / Evolução Biológica / Neoplasias Tipo de estudo: Prevalence_studies / Prognostic_studies / Risk_factors_studies Limite: Aged / Humans / Male Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2015 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Seleção Genética / Variação Genética / Evolução Biológica / Neoplasias Tipo de estudo: Prevalence_studies / Prognostic_studies / Risk_factors_studies Limite: Aged / Humans / Male Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2015 Tipo de documento: Article