Bacterial chromosome organization and segregation.
Annu Rev Cell Dev Biol
; 31: 171-99, 2015.
Article
em En
| MEDLINE
| ID: mdl-26566111
ABSTRACT
If fully stretched out, a typical bacterial chromosome would be nearly 1 mm long, approximately 1,000 times the length of a cell. Not only must cells massively compact their genetic material, but they must also organize their DNA in a manner that is compatible with a range of cellular processes, including DNA replication, DNA repair, homologous recombination, and horizontal gene transfer. Recent work, driven in part by technological advances, has begun to reveal the general principles of chromosome organization in bacteria. Here, drawing on studies of many different organisms, we review the emerging picture of how bacterial chromosomes are structured at multiple length scales, highlighting the functions of various DNA-binding proteins and the impact of physical forces. Additionally, we discuss the spatial dynamics of chromosomes, particularly during their segregation to daughter cells. Although there has been tremendous progress, we also highlight gaps that remain in understanding chromosome organization and segregation.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Bactérias
/
Cromossomos Bacterianos
/
Segregação de Cromossomos
Limite:
Animals
Idioma:
En
Revista:
Annu Rev Cell Dev Biol
Assunto da revista:
BIOLOGIA
Ano de publicação:
2015
Tipo de documento:
Article