Distinct Splice Variants of Dynamin-related Protein 1 Differentially Utilize Mitochondrial Fission Factor as an Effector of Cooperative GTPase Activity.

Macdonald, Patrick J; Francy, Christopher A; Stepanyants, Natalia; Lehman, Lance; Baglio, Anthony; Mears, Jason A; Qi, Xin; Ramachandran, Rajesh

Macdonald, Patrick J; Francy, Christopher A; Stepanyants, Natalia; Lehman, Lance; Baglio, Anthony; Mears, Jason A; Qi, Xin; Ramachandran, Rajesh.

Afiliação

Macdonald PJ; From the Department of Physiology and Biophysics.
Francy CA; Department of Pharmacology, Center for Mitochondrial Diseases, and Cleveland Center for Membrane and Structural Biology, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106.
Stepanyants N; From the Department of Physiology and Biophysics.
Lehman L; From the Department of Physiology and Biophysics.
Baglio A; From the Department of Physiology and Biophysics.
Mears JA; Department of Pharmacology, Center for Mitochondrial Diseases, and Cleveland Center for Membrane and Structural Biology, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106.
Qi X; From the Department of Physiology and Biophysics, Center for Mitochondrial Diseases, and.
Ramachandran R; From the Department of Physiology and Biophysics, Cleveland Center for Membrane and Structural Biology, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106 rxr275@case.edu.

J Biol Chem ; 291(1): 493-507, 2016 Jan 01.

Article em En | MEDLINE | ID: mdl-26578513

Assuntos

Dinaminas/genética; GTP Fosfo-Hidrolases/metabolismo; Proteínas de Membrana/metabolismo; Proteínas Associadas aos Microtúbulos/metabolismo; Proteínas Mitocondriais/metabolismo; Splicing de RNA/genética; Animais; Cardiolipinas/metabolismo; Membrana Celular/metabolismo; Dinaminas/metabolismo; GTP Fosfo-Hidrolases/química; GTP Fosfo-Hidrolases/ultraestrutura; Guanosina Trifosfato/metabolismo; Humanos; Hidrólise; Cinética; Camundongos Knockout; Proteínas Associadas aos Microtúbulos/química; Proteínas Associadas aos Microtúbulos/ultraestrutura; Proteínas Mitocondriais/química; Proteínas Mitocondriais/ultraestrutura; Multimerização Proteica; Estrutura Secundária de Proteína; Ratos

Palavras-chave

GTPase; alternative splicing; cardiolipin; dynamin-related protein 1; fluorescence resonance energy transfer (FRET); isoforms; mitochondria; mitochondrial dynamics; mitochondrial fission factor

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Splicing de RNA / Proteínas Mitocondriais / Dinaminas / GTP Fosfo-Hidrolases / Proteínas de Membrana / Proteínas Associadas aos Microtúbulos Limite: Animals / Humans Idioma: En Revista: J Biol Chem Ano de publicação: 2016 Tipo de documento: Article

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