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Evaluation of a Live-Attenuated Human Parainfluenza Type 1 Vaccine in Adults and Children.
Karron, Ruth A; San Mateo, Jocelyn; Thumar, Bhagvanji; Schaap-Nutt, Anne; Buchholz, Ursula J; Schmidt, Alexander C; Bartlett, Emmalene J; Murphy, Brian R; Collins, Peter L.
Afiliação
  • Karron RA; Center for Immunization Research, Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.
  • San Mateo J; Center for Immunization Research, Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.
  • Thumar B; Center for Immunization Research, Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.
  • Schaap-Nutt A; Respiratory Viruses Section, Laboratory of Infectious Diseases, National Institute of Allergy, Immunology, and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.
  • Buchholz UJ; Respiratory Viruses Section, Laboratory of Infectious Diseases, National Institute of Allergy, Immunology, and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.
  • Schmidt AC; Respiratory Viruses Section, Laboratory of Infectious Diseases, National Institute of Allergy, Immunology, and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.
  • Bartlett EJ; Respiratory Viruses Section, Laboratory of Infectious Diseases, National Institute of Allergy, Immunology, and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.
  • Murphy BR; Respiratory Viruses Section, Laboratory of Infectious Diseases, National Institute of Allergy, Immunology, and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.
  • Collins PL; Respiratory Viruses Section, Laboratory of Infectious Diseases, National Institute of Allergy, Immunology, and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.
J Pediatric Infect Dis Soc ; 4(4): e143-6, 2015 Dec.
Article em En | MEDLINE | ID: mdl-26582883
ABSTRACT
We conducted a phase I clinical trial (clinicaltrials.gov identifier, NCT00641017) of the experimental live-attenuated human parainfluenza virus type 1 (HPIV-1) vaccine rHPIV-1/84/del 170/942A sequentially in 3 groups adults, HPIV-1-seropositive children, and HPIV-1-seronegative children, the target population for vaccination. rHPIV-1/84/del 170/942A was appropriately restricted in replication in adults and HPIV-1-seropositive children but was overattenuated (ie, insufficiently infectious and immunogenic) for HPIV-1-seronegative children.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Infecções por Paramyxoviridae / Vacinas contra Parainfluenza Tipo de estudo: Clinical_trials Limite: Adult / Child, preschool / Humans / Infant Idioma: En Revista: J Pediatric Infect Dis Soc Ano de publicação: 2015 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Infecções por Paramyxoviridae / Vacinas contra Parainfluenza Tipo de estudo: Clinical_trials Limite: Adult / Child, preschool / Humans / Infant Idioma: En Revista: J Pediatric Infect Dis Soc Ano de publicação: 2015 Tipo de documento: Article