Evaluation of a Live-Attenuated Human Parainfluenza Type 1 Vaccine in Adults and Children.
J Pediatric Infect Dis Soc
; 4(4): e143-6, 2015 Dec.
Article
em En
| MEDLINE
| ID: mdl-26582883
ABSTRACT
We conducted a phase I clinical trial (clinicaltrials.gov identifier, NCT00641017) of the experimental live-attenuated human parainfluenza virus type 1 (HPIV-1) vaccine rHPIV-1/84/del 170/942A sequentially in 3 groups adults, HPIV-1-seropositive children, and HPIV-1-seronegative children, the target population for vaccination. rHPIV-1/84/del 170/942A was appropriately restricted in replication in adults and HPIV-1-seropositive children but was overattenuated (ie, insufficiently infectious and immunogenic) for HPIV-1-seronegative children.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Infecções por Paramyxoviridae
/
Vacinas contra Parainfluenza
Tipo de estudo:
Clinical_trials
Limite:
Adult
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Child, preschool
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Humans
/
Infant
Idioma:
En
Revista:
J Pediatric Infect Dis Soc
Ano de publicação:
2015
Tipo de documento:
Article