Heartwater--Ehrlichia ruminantium infection.
Rev Sci Tech
; 34(2): 557-68, 2015 Aug.
Article
em En
| MEDLINE
| ID: mdl-26601456
ABSTRACT
Summary Heartwater is a notifiable disease that is listed by the World Organisation for Animal Health. It is caused by Ehrlichia ruminantium, an obligately intracellular Gram-negative bacterium in the order Rickettsiales and the family Anaplasmataceae. The disease is borne byticks in the genus Amblyomma and causes heartwater, or cowdriosis, in wild and domestic ruminants, primarily in Africa, but also in parts of the Caribbean. The disease was recognised in South Africa in the 19th Century and determined to be tick borne in 1900, while the organism was identified in 1925 and first cultured in vitro in 1985. This latter achievement boosted research into the disease at a time when biology was moving into the molecular genetic age. Over the last 20 years, there have been significant improvements in our understanding of E. ruminantium, yielding major advances in diagnosis, epidemiology, genetic characterisation, phylogeny, immunology, and vaccine development. The organism is genetically highly variable; this has important implications for future control measures, and is making it difficult to develop an effective vaccine for protection against tick challenge. Research is continuing into three different types of vaccine, inactivated, attenuated, and recombinant, and the current state of development of each is discussed.
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Base de dados:
MEDLINE
Assunto principal:
Ehrlichia ruminantium
/
Hidropericárdio
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
Rev Sci Tech
Assunto da revista:
DOENCAS TRANSMISSIVEIS
/
MEDICINA VETERINARIA
Ano de publicação:
2015
Tipo de documento:
Article