Hypoxia-inducible factor-1&#945; perpetuates synovial fibroblast interactions with T cells and B cells in rheumatoid arthritis.

Hu, Fanlei; Liu, Hongjiang; Xu, Liling; Li, Yingni; Liu, Xu; Shi, Lianjie; Su, Yin; Qiu, Xiaoyan; Zhang, Xia; Yang, Yuqin; Zhang, Jian; Li, Zhanguo

Hypoxia-inducible factor-1α perpetuates synovial fibroblast interactions with T cells and B cells in rheumatoid arthritis.

Hu, Fanlei; Liu, Hongjiang; Xu, Liling; Li, Yingni; Liu, Xu; Shi, Lianjie; Su, Yin; Qiu, Xiaoyan; Zhang, Xia; Yang, Yuqin; Zhang, Jian; Li, Zhanguo.

Afiliação

Hu F; Department of Rheumatology and Immunology, Peking University People's Hospital & Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135), Beijing, China.
Liu H; Department of Rheumatology and Immunology, Peking University People's Hospital & Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135), Beijing, China.
Xu L; Department of Rheumatology and Immunology, Peking University People's Hospital & Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135), Beijing, China.
Li Y; Department of Rheumatology and Immunology, Peking University People's Hospital & Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135), Beijing, China.
Liu X; Department of Rheumatology and Immunology, Peking University People's Hospital & Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135), Beijing, China.
Shi L; Department of Rheumatology and Immunology, Peking University People's Hospital & Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135), Beijing, China.
Su Y; Department of Rheumatology and Immunology, Peking University People's Hospital & Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135), Beijing, China.
Qiu X; Department of Immunology, School of Basic Medical Science, Peking University, Beijing, China.
Zhang X; Department of Rheumatology and Immunology, Peking University People's Hospital & Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135), Beijing, China.
Yang Y; Department of Rheumatology and Immunology, Peking University People's Hospital & Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135), Beijing, China.
Zhang J; Department of Rheumatology and Immunology, Peking University People's Hospital & Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135), Beijing, China.
Li Z; Department of Rheumatology and Immunology, Peking University People's Hospital & Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135), Beijing, China.

Eur J Immunol ; 46(3): 742-51, 2016 Mar.

Article em En | MEDLINE | ID: mdl-26604208

Assuntos

Artrite Reumatoide/imunologia; Linfócitos B/imunologia; Fibroblastos/imunologia; Fibroblastos/fisiologia; Subunidade alfa do Fator 1 Induzível por Hipóxia/metabolismo; Linfócitos T/imunologia; Autoanticorpos/biossíntese; Células Cultivadas; Quimiocina CXCL12/genética; Citocinas/genética; Técnicas de Silenciamento de Genes; Humanos; Subunidade alfa do Fator 1 Induzível por Hipóxia/deficiência; Subunidade alfa do Fator 1 Induzível por Hipóxia/genética; Interleucina-15/genética; Interleucina-17/imunologia; Interleucina-17/fisiologia; Interleucina-6/genética; Interleucina-8/genética; Membrana Sinovial/citologia; Trombospondina 1/genética; Molécula 1 de Adesão de Célula Vascular/genética

Palavras-chave

B cell; Hypoxia-inducible factor-1α; Rheumatoid arthritis; Synovial fibroblast; T cell

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Artrite Reumatoide / Linfócitos B / Linfócitos T / Subunidade alfa do Fator 1 Induzível por Hipóxia / Fibroblastos Limite: Humans Idioma: En Revista: Eur J Immunol Ano de publicação: 2016 Tipo de documento: Article País de afiliação: China

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