Allergen immunotherapy and respiratory infections in children: an encouraging experience.
Minerva Pediatr
; 70(1): 1-4, 2018 Feb.
Article
em En
| MEDLINE
| ID: mdl-26605703
ABSTRACT
BACKGROUND:
Allergic inflammation may promote respiratory infections (RI). House dust mite (HDM) sensitization is common in childhood. Allergen immunotherapy may cure allergy as it restores a physiological immune and clinical tolerance toward the causal allergen and exerts anti-inflammatory activity. This study retrospectively investigated whether 3 year high-dose HDM-sublingual immunotherapy (SLIT) could affect respiratory infections in children with allergic rhinitis.METHODS:
Globally, 33 HDM allergic children (18 males, mean age 9.3 years) were subdivided in 2 groups 20 treated with symptomatic drugs alone (group 1) and 13 by high-dose SLIT, titrated in mcg of major allergens (group 2) for 3 years.RESULTS:
SLIT-treated children had significantly (P=0.01) less RI episodes (3.6) than symptomatically-treated children (5.4). In addition, SLIT-treated children had less fever (P<0.01) and took fewer medications, such as antibiotics (P<0.05) and fever-reducers (P<0.01), than symptomatically-treated children.CONCLUSIONS:
This preliminary study suggests that high-dose 3-year SLIT might lessen RI in allergic children.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Infecções Respiratórias
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Pyroglyphidae
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Imunoterapia Sublingual
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Rinite Alérgica
Tipo de estudo:
Etiology_studies
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Observational_studies
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Risk_factors_studies
Limite:
Adolescent
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Animals
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Child
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Female
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Humans
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Male
Idioma:
En
Revista:
Minerva Pediatr
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Itália