HSV targeting of the host phosphatase PP1&#945; is required for disseminated disease in the neonate and contributes to pathogenesis in the brain.

Wilcox, Douglas R; Muller, William J; Longnecker, Richard

HSV targeting of the host phosphatase PP1α is required for disseminated disease in the neonate and contributes to pathogenesis in the brain.

Wilcox, Douglas R; Muller, William J; Longnecker, Richard.

Afiliação

Wilcox DR; Department of Microbiology and Immunology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611; Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, IL 60611.
Muller WJ; Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, IL 60611.
Longnecker R; Department of Microbiology and Immunology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611; r-longnecker@northwestern.edu.

Proc Natl Acad Sci U S A ; 112(50): E6937-44, 2015 Dec 15.

Article em En | MEDLINE | ID: mdl-26621722

Assuntos

Encefalopatias/patologia; Herpes Simples/patologia; Fosfoproteínas Fosfatases/metabolismo; Simplexvirus/fisiologia; Animais; Animais Recém-Nascidos; Fator de Iniciação 2 em Eucariotos/metabolismo; Técnicas In Vitro; Camundongos; Fosforilação; Simplexvirus/patogenicidade; Virulência

Palavras-chave

HSV-1; disseminated disease; interferon response; translational arrest

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Encefalopatias / Simplexvirus / Fosfoproteínas Fosfatases / Herpes Simples Tipo de estudo: Etiology_studies / Prognostic_studies Limite: Animals Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2015 Tipo de documento: Article

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