Your browser doesn't support javascript.
loading
Characterization of a new subtype of allergen in dermatophagoides farinae-Der f 28.
Lin, Jian-Li; Wang, Yuan-Yuan; Xiao, Xiao-Jun; Wu, Yu-Lan; Sun, Bao-Qing; Gao, An-Jian; Liu, Zhi-Gang; Li, Jing; Yang, Ping-Chang; Liu, Xiao-Yu.
Afiliação
  • Lin JL; 1 State Key Laboratory of Respiratory Disease for Allergy, School of Medicine, Shenzhen University, Shenzhen 518060,, China ; 2 State Key Laboratory of Respiratory Disease, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou 510120, China.
  • Wang YY; 1 State Key Laboratory of Respiratory Disease for Allergy, School of Medicine, Shenzhen University, Shenzhen 518060,, China ; 2 State Key Laboratory of Respiratory Disease, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou 510120, China.
  • Xiao XJ; 1 State Key Laboratory of Respiratory Disease for Allergy, School of Medicine, Shenzhen University, Shenzhen 518060,, China ; 2 State Key Laboratory of Respiratory Disease, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou 510120, China.
  • Wu YL; 1 State Key Laboratory of Respiratory Disease for Allergy, School of Medicine, Shenzhen University, Shenzhen 518060,, China ; 2 State Key Laboratory of Respiratory Disease, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou 510120, China.
  • Sun BQ; 1 State Key Laboratory of Respiratory Disease for Allergy, School of Medicine, Shenzhen University, Shenzhen 518060,, China ; 2 State Key Laboratory of Respiratory Disease, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou 510120, China.
  • Gao AJ; 1 State Key Laboratory of Respiratory Disease for Allergy, School of Medicine, Shenzhen University, Shenzhen 518060,, China ; 2 State Key Laboratory of Respiratory Disease, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou 510120, China.
  • Liu ZG; 1 State Key Laboratory of Respiratory Disease for Allergy, School of Medicine, Shenzhen University, Shenzhen 518060,, China ; 2 State Key Laboratory of Respiratory Disease, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou 510120, China.
  • Li J; 1 State Key Laboratory of Respiratory Disease for Allergy, School of Medicine, Shenzhen University, Shenzhen 518060,, China ; 2 State Key Laboratory of Respiratory Disease, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou 510120, China.
  • Yang PC; 1 State Key Laboratory of Respiratory Disease for Allergy, School of Medicine, Shenzhen University, Shenzhen 518060,, China ; 2 State Key Laboratory of Respiratory Disease, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou 510120, China.
  • Liu XY; 1 State Key Laboratory of Respiratory Disease for Allergy, School of Medicine, Shenzhen University, Shenzhen 518060,, China ; 2 State Key Laboratory of Respiratory Disease, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou 510120, China.
J Thorac Dis ; 7(10): 1842-9, 2015 Oct.
Article em En | MEDLINE | ID: mdl-26623108
BACKGROUND: House dust mites (HDMs) are the major sources of indoor allergens which induce asthma, dermatitis, rhinitis, and some other allergic diseases. Close to 30 sub-allergens have been identified. METHODS: Through analyzing the full genome sequence of dust mite, a new allergen whose primary structure belongs to the heat shock protein family was identified. The sequence of this allergen was determined by cDNA cloning. The allergenicity was assayed by skin prick test, Western-blot and enzyme-linked immunosorbent assay (ELISA). RESULTS: r-Der f 28 bound to serum IgE from mite allergic patients. Positive responses to r-Der f 28 were shown in 11.5% by skin prick testing from 26 DM-allergic patients. Airway hyperresponsiveness, serum specific IgE and IL-4 were significantly increased in allergic asthma mouse model sensitized to r-Der f 28. CONCLUSIONS: Der f 28 is a new subtype of allergen in dermatophagoides farinae.
Palavras-chave
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Idioma: En Revista: J Thorac Dis Ano de publicação: 2015 Tipo de documento: Article País de afiliação: China
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Idioma: En Revista: J Thorac Dis Ano de publicação: 2015 Tipo de documento: Article País de afiliação: China