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Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation.
Soler Artigas, María; Wain, Louise V; Miller, Suzanne; Kheirallah, Abdul Kader; Huffman, Jennifer E; Ntalla, Ioanna; Shrine, Nick; Obeidat, Ma'en; Trochet, Holly; McArdle, Wendy L; Alves, Alexessander Couto; Hui, Jennie; Zhao, Jing Hua; Joshi, Peter K; Teumer, Alexander; Albrecht, Eva; Imboden, Medea; Rawal, Rajesh; Lopez, Lorna M; Marten, Jonathan; Enroth, Stefan; Surakka, Ida; Polasek, Ozren; Lyytikäinen, Leo-Pekka; Granell, Raquel; Hysi, Pirro G; Flexeder, Claudia; Mahajan, Anubha; Beilby, John; Bossé, Yohan; Brandsma, Corry-Anke; Campbell, Harry; Gieger, Christian; Gläser, Sven; González, Juan R; Grallert, Harald; Hammond, Chris J; Harris, Sarah E; Hartikainen, Anna-Liisa; Heliövaara, Markku; Henderson, John; Hocking, Lynne; Horikoshi, Momoko; Hutri-Kähönen, Nina; Ingelsson, Erik; Johansson, Åsa; Kemp, John P; Kolcic, Ivana; Kumar, Ashish; Lind, Lars.
Afiliação
  • Soler Artigas M; Genetic Epidemiology Group, Department of Health Sciences, University of Leicester, Leicester LE1 7RH, UK.
  • Wain LV; Genetic Epidemiology Group, Department of Health Sciences, University of Leicester, Leicester LE1 7RH, UK.
  • Miller S; Division of Respiratory Medicine, Queen's Medical Centre, University of Nottingham, Nottingham NG7 2RD, UK.
  • Kheirallah AK; Division of Respiratory Medicine, Queen's Medical Centre, University of Nottingham, Nottingham NG7 2RD, UK.
  • Huffman JE; MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, Scotland EH8 9AD, UK.
  • Ntalla I; Genetic Epidemiology Group, Department of Health Sciences, University of Leicester, Leicester LE1 7RH, UK.
  • Shrine N; Genetic Epidemiology Group, Department of Health Sciences, University of Leicester, Leicester LE1 7RH, UK.
  • Obeidat M; University of British Columbia Centre for Heart Lung Innovation, St Paul's Hospital, Vancouver, British Columbia, Canada V6Z 1Y6.
  • Trochet H; MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, Scotland EH8 9AD, UK.
  • McArdle WL; Generation Scotland, A Collaboration between the University Medical Schools and NHS, Aberdeen, Dundee, Edinburgh, Glasgow EH4 2XU, UK.
  • Alves AC; School of Social and Community Medicine, University of Bristol, Bristol BS8 1TH, UK.
  • Hui J; Department of Epidemiology and Biostatistics, MRC -PHE Centre for Environment &Health, School of Public Health, Imperial College London, London SW7 2AZ, UK.
  • Zhao JH; Busselton Population Medical Research Institute, Busselton, Western Australia 6280, Australia.
  • Joshi PK; PathWest Laboratory Medicine WA, Sir Charles Gairdner Hospital, Western Australia 6009, Australia.
  • Teumer A; School of Population Health, The University of Western Australia, Western Australia 6009, Australia.
  • Albrecht E; School of Pathology and Laboratory Medicine, The University of Western Australia, Western Australia 6009, Australia.
  • Imboden M; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge CB2 0SL, UK.
  • Rawal R; Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Teviot Place, Edinburgh EH8 9AD, Scotland, UK.
  • Lopez LM; University Medicine Greifswald, Community Medicine, SHIP-Clinical Epidemiological Research, Greifswald 17489, Germany.
  • Marten J; Department for Genetics and Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald 17489, Germany.
  • Enroth S; Institute of Genetic Epidemiology, Helmholtz Zentrum München German Research Center for Environmental Health, Neuherberg D-85764, Germany.
  • Surakka I; Swiss Tropical and Public Health Institute, Basel 4051, Switzerland.
  • Polasek O; University of Basel, Basel 4001, Switzerland.
  • Lyytikäinen LP; Institute of Genetic Epidemiology, Helmholtz Zentrum München German Research Center for Environmental Health, Neuherberg D-85764, Germany.
  • Granell R; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg D-85764, Germany.
  • Hysi PG; Institute of Epidemiology II, Helmholtz Zentrum München German Research Center for Environmental Health, Neuherberg D-85764, Germany.
  • Flexeder C; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh EH8 9AD, UK.
  • Mahajan A; Department of Psychology, University of Edinburgh, Edinburgh EH8 9AD, UK.
  • Beilby J; MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, Scotland EH8 9AD, UK.
  • Bossé Y; Department of Immunology, Genetics, and Pathology, Biomedical Center, SciLifeLab Uppsala, Uppsala University, Uppsala 751 23, Sweden.
  • Brandsma CA; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki FI-00014, Finland.
  • Campbell H; The National Institute for Health and Welfare (THL), Helsinki FI-00271, Finland.
  • Gieger C; Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Teviot Place, Edinburgh EH8 9AD, Scotland, UK.
  • Gläser S; Department of Public Health, Faculty of Medicine, University of Split, Split 21000, Croatia.
  • González JR; Department of Clinical Chemistry, Fimlab Laboratories, Tampere FI-33101, Finland.
  • Grallert H; Department of Clinical Chemistry, University of Tampere School of Medicine, Tampere FI-33520, Finland.
  • Hammond CJ; School of Social and Community Medicine, University of Bristol, Bristol BS8 1TH, UK.
  • Harris SE; KCL Department of Twins Research and Genetic Epidemiology, King's College London, London WC2R 2LS, UK.
  • Hartikainen AL; Institute of Epidemiology I, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg D-85764, Germany.
  • Heliövaara M; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
  • Henderson J; Busselton Population Medical Research Institute, Busselton, Western Australia 6280, Australia.
  • Hocking L; PathWest Laboratory Medicine WA, Sir Charles Gairdner Hospital, Western Australia 6009, Australia.
  • Horikoshi M; School of Pathology and Laboratory Medicine, The University of Western Australia, Western Australia 6009, Australia.
  • Hutri-Kähönen N; Department of Molecular Medicine, Institut Universitaire de Cardiologie et de Pneumologie de Québec, Laval University, Québec, Canada G1V 0A6.
  • Ingelsson E; Department of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, Groningen 9700, The Netherlands.
  • Johansson Å; Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Teviot Place, Edinburgh EH8 9AD, Scotland, UK.
  • Kemp JP; Institute of Genetic Epidemiology, Helmholtz Zentrum München German Research Center for Environmental Health, Neuherberg D-85764, Germany.
  • Kolcic I; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg D-85764, Germany.
  • Kumar A; Institute of Epidemiology II, Helmholtz Zentrum München German Research Center for Environmental Health, Neuherberg D-85764, Germany.
  • Lind L; Department of Internal Medicine B, Pneumology, Cardiology, Intensive Care, Weaning, Field of Research: Pneumological Epidemiology, University Medicine Greifswald, Greifswald 17489, Germany.
Nat Commun ; 6: 8658, 2015 Dec 04.
Article em En | MEDLINE | ID: mdl-26635082
ABSTRACT
Lung function measures are used in the diagnosis of chronic obstructive pulmonary disease. In 38,199 European ancestry individuals, we studied genome-wide association of forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC) and FEV1/FVC with 1000 Genomes Project (phase 1)-imputed genotypes and followed up top associations in 54,550 Europeans. We identify 14 novel loci (P<5 × 10(-8)) in or near ENSA, RNU5F-1, KCNS3, AK097794, ASTN2, LHX3, CCDC91, TBX3, TRIP11, RIN3, TEKT5, LTBP4, MN1 and AP1S2, and two novel signals at known loci NPNT and GPR126, providing a basis for new understanding of the genetic determinants of these traits and pulmonary diseases in which they are altered.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Estudo de Associação Genômica Ampla / Pulmão / Pneumopatias Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Reino Unido
Texto completo
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PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Estudo de Associação Genômica Ampla / Pulmão / Pneumopatias Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Reino Unido