Synergistic Myeloma Cell Death via Novel Intracellular Activation of Caspase-10-Dependent Apoptosis by Carfilzomib and Selinexor.

Rosebeck, Shaun; Alonge, Mattina M; Kandarpa, Malathi; Mayampurath, Anoop; Volchenboum, Samuel L; Jasielec, Jagoda; Dytfeld, Dominik; Maxwell, Sean P; Kraftson, Stephanie J; McCauley, Dilara; Shacham, Sharon; Kauffman, Michael; Jakubowiak, Andrzej J

Rosebeck, Shaun; Alonge, Mattina M; Kandarpa, Malathi; Mayampurath, Anoop; Volchenboum, Samuel L; Jasielec, Jagoda; Dytfeld, Dominik; Maxwell, Sean P; Kraftson, Stephanie J; McCauley, Dilara; Shacham, Sharon; Kauffman, Michael; Jakubowiak, Andrzej J.

Afiliação

Rosebeck S; Department of Medicine, University of Chicago, Chicago, Illinois.
Alonge MM; Department of Medicine, University of Chicago, Chicago, Illinois.
Kandarpa M; University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan.
Mayampurath A; Computation Institute, University of Chicago, Chicago, Illinois.
Volchenboum SL; Computation Institute, University of Chicago, Chicago, Illinois.
Jasielec J; Department of Medicine, University of Chicago, Chicago, Illinois.
Dytfeld D; Poznan University of Medical Sciences, Poznan, Poland.
Maxwell SP; Department of Medicine, University of Chicago, Chicago, Illinois.
Kraftson SJ; University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan.
McCauley D; Karyopharm Therapeutics, Newton, Massachusetts.
Shacham S; Karyopharm Therapeutics, Newton, Massachusetts.
Kauffman M; Karyopharm Therapeutics, Newton, Massachusetts.
Jakubowiak AJ; Department of Medicine, University of Chicago, Chicago, Illinois. ajakubowiak@medicine.bsd.uchicago.edu.

Mol Cancer Ther ; 15(1): 60-71, 2016 Jan.

Article em En | MEDLINE | ID: mdl-26637366

Assuntos

Apoptose/efeitos dos fármacos; Caspase 10/metabolismo; Hidrazinas/farmacologia; Mieloma Múltiplo/metabolismo; Oligopeptídeos/farmacologia; Triazóis/farmacologia; Animais; Antineoplásicos/farmacologia; Autofagia/efeitos dos fármacos; Caspase 8/metabolismo; Linhagem Celular Tumoral; Modelos Animais de Doenças; Sinergismo Farmacológico; Ativação Enzimática/efeitos dos fármacos; Humanos; Espaço Intracelular; Camundongos; Inibidores de Proteassoma/farmacologia; Ensaios Antitumorais Modelo de Xenoenxerto

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Oligopeptídeos / Triazóis / Apoptose / Caspase 10 / Hidrazinas / Mieloma Múltiplo Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Mol Cancer Ther Assunto da revista: ANTINEOPLASICOS Ano de publicação: 2016 Tipo de documento: Article

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