WNT signaling in glioblastoma and therapeutic opportunities.
Lab Invest
; 96(2): 137-50, 2016 Feb.
Article
em En
| MEDLINE
| ID: mdl-26641068
ABSTRACT
WNTs and their downstream effectors regulate proliferation, death, and migration and cell fate decision. Deregulation of WNT signaling is associated with various cancers including GBM, which is the most malignant primary brain cancer. In this review, we will summarize the experimental evidence supporting oncogenic roles of WNT signaling in GBM and discuss current progress in the targeting of WNT signaling as an anti-cancer approach. In particular, we will focus on (1) genetic and epigenetic alterations that lead to aberrant WNT pathway activation in GBM, (2) WNT-mediated control of GBM stem cell maintenance and invasion, and (3) cross-talk between WNT and other signaling pathways in GBM. We will then review the discovery of agents that can inhibit WNT signaling in preclinical models and the current status of human clinical trials.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Encefálicas
/
Glioblastoma
/
Via de Sinalização Wnt
Tipo de estudo:
Prognostic_studies
Limite:
Humans
Idioma:
En
Revista:
Lab Invest
Ano de publicação:
2016
Tipo de documento:
Article
País de afiliação:
Coréia do Sul