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Serum Iron Level Is Associated with Time to Antibiotics in Cystic Fibrosis.
Gifford, Alex H; Dorman, Dana B; Moulton, Lisa A; Helm, Jennifer E; Griffin, Mary M; MacKenzie, Todd A.
Afiliação
  • Gifford AH; Department of Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire, USA.
  • Dorman DB; Translational Research Core, Dartmouth Lung Biology Center, Lebanon, New Hampshire, USA.
  • Moulton LA; Translational Research Core, Dartmouth Lung Biology Center, Lebanon, New Hampshire, USA.
  • Helm JE; Translational Research Core, Dartmouth Lung Biology Center, Lebanon, New Hampshire, USA.
  • Griffin MM; Translational Research Core, Dartmouth Lung Biology Center, Lebanon, New Hampshire, USA.
  • MacKenzie TA; Department of Community and Family Medicine, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA.
Clin Transl Sci ; 8(6): 754-8, 2015 Dec.
Article em En | MEDLINE | ID: mdl-26643575
BACKGROUND: Serum levels of hepcidin-25, a peptide hormone that reduces blood iron content, are elevated when patients with cystic fibrosis (CF) develop pulmonary exacerbation (PEx). Because hepcidin-25 is unavailable as a clinical laboratory test, we questioned whether a one-time serum iron level was associated with the subsequent number of days until PEx, as defined by the need to receive systemic antibiotics (ABX) for health deterioration. METHODS: Clinical, biochemical, and microbiological parameters were simultaneously checked in 54 adults with CF. Charts were reviewed to determine when they first experienced a PEx after these parameters were assessed. Time to ABX was compared in subgroups with and without specific attributes. Multivariate linear regression was used to identify parameters that significantly explained variation in time to ABX. RESULTS: In univariate analyses, time to ABX was significantly shorter in subjects with Aspergillus-positive sputum cultures and CF-related diabetes. Multivariate linear regression models demonstrated that shorter time to ABX was associated with younger age, lower serum iron level, and Aspergillus sputum culture positivity. CONCLUSIONS: Serum iron, age, and Aspergillus sputum culture positivity are factors associated with shorter time to subsequent PEx in CF adults.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fibrose Cística / Ferro / Antibacterianos Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Adolescent / Adult / Child / Female / Humans / Male Idioma: En Revista: Clin Transl Sci Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fibrose Cística / Ferro / Antibacterianos Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Adolescent / Adult / Child / Female / Humans / Male Idioma: En Revista: Clin Transl Sci Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Estados Unidos