Causal Influence of Visual Cues on Hippocampal Directional Selectivity.
Cell
; 164(1-2): 197-207, 2016 Jan 14.
Article
em En
| MEDLINE
| ID: mdl-26709045
ABSTRACT
Hippocampal neurons show selectivity with respect to visual cues in primates, including humans, but this has never been found in rodents. To address this long-standing discrepancy, we measured hippocampal activity from rodents during real-world random foraging. Surprisingly, â¼ 25% of neurons exhibited significant directional modulation with respect to visual cues. To dissociate the contributions of visual and vestibular cues, we made similar measurements in virtual reality, in which only visual cues were informative. Here, we found significant directional modulation despite the severe loss of vestibular information, challenging prevailing theories of directionality. Changes in the amount of angular information in visual cues induced corresponding changes in head-directional modulation at the neuronal and population levels. Thus, visual cues are sufficient for-and play a predictable, causal role in-generating directionally selective hippocampal responses. These results dissociate hippocampal directional and spatial selectivity and bridge the gap between primate and rodent studies.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Comportamento Apetitivo
/
Hipocampo
Limite:
Animals
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Humans
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Male
Idioma:
En
Revista:
Cell
Ano de publicação:
2016
Tipo de documento:
Article
País de afiliação:
Estados Unidos