Pathophysiology of neutrophil-mediated extracellular redox reactions.
Front Biosci (Landmark Ed)
; 21(4): 839-55, 2016 01 01.
Article
em En
| MEDLINE
| ID: mdl-26709808
ABSTRACT
Neutrophil granulocyte leukocytes (neutrophils) play fundamental role in the innate immune response. In the presence of adequate stimuli, neutrophils release excessive amount of reactive oxygen species (ROS) that may induce cell and tissue injury. Oxidative burst of neutrophils acts as a double-edged sword. It may contribute to the pathology of atherosclerosis and brain injury but is also necessary in resolving infections. Moreover, neutrophil-derived ROS may also have both a tumor promoting and tumor suppressing role. ROS have a specific activities and diffusion distance, which is related to their short lifetime. Therefore, the manner in which ROS will act depends on the cells targeted and the intra- and extracellular levels of individual ROS, which can further cause production of reactive aldehydes like 4-hydroxynonenal (HNE) that act as a second messengers of ROS. In this review we discuss the influence of neutrophil mediated extracellular redox reactions in ischemia reperfusion injury, transplant rejection and chronic diseases (atherosclerosis, inflammatory bowel diseases and cancer). At the end a brief overview of cellular mechanisms to maintain ROS homeostasis is given.
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Base de dados:
MEDLINE
Assunto principal:
Matriz Extracelular
/
Neutrófilos
Limite:
Humans
Idioma:
En
Revista:
Front Biosci (Landmark Ed)
Ano de publicação:
2016
Tipo de documento:
Article