5-Fluoro derivatives of 4-epi-isofagomine as D-galactosidase inhibitors and potential pharmacological chaperones for GM1-gangliosidosis as well as Fabry's disease.

Thonhofer, Martin; Gonzalez Santana, Andres; Fischer, Roland; Torvisco Gomez, Ana; Saf, Robert; Schalli, Michael; Stütz, Arnold E; Withers, Stephen G

Thonhofer, Martin; Gonzalez Santana, Andres; Fischer, Roland; Torvisco Gomez, Ana; Saf, Robert; Schalli, Michael; Stütz, Arnold E; Withers, Stephen G.

Afiliação

Thonhofer M; Glycogroup, Institute for Organic Chemistry, Graz University of Technology, Stremayrgasse 9, A-8010 Graz, Austria.
Gonzalez Santana A; Chemistry Department, University of British Columbia, 2036 Main Mall, Vancouver, BC, Canada V6T 1Z1.
Fischer R; Institute for Inorganic Chemistry, Graz University of Technology, Stremayrgasse 9, A-8010 Graz, Austria.
Torvisco Gomez A; Institute for Inorganic Chemistry, Graz University of Technology, Stremayrgasse 9, A-8010 Graz, Austria.
Saf R; Institute for Chemistry and Technology of Materials, Graz University of Technology, Stremayrgasse 9, A-8010 Graz, Austria.
Schalli M; Glycogroup, Institute for Organic Chemistry, Graz University of Technology, Stremayrgasse 9, A-8010 Graz, Austria.
Stütz AE; Glycogroup, Institute for Organic Chemistry, Graz University of Technology, Stremayrgasse 9, A-8010 Graz, Austria. Electronic address: stuetz@tugraz.at.
Withers SG; Chemistry Department, University of British Columbia, 2036 Main Mall, Vancouver, BC, Canada V6T 1Z1.

Carbohydr Res ; 420: 6-12, 2016 Feb.

Article em En | MEDLINE | ID: mdl-26717544

Assuntos

Inibidores Enzimáticos/síntese química; Galactosidases/antagonistas & inibidores; Imino Piranoses/síntese química; Inibidores Enzimáticos/química; Inibidores Enzimáticos/farmacologia; Doença de Fabry/tratamento farmacológico; Doença de Fabry/enzimologia; Gangliosidose GM1/tratamento farmacológico; Gangliosidose GM1/enzimologia; Halogenação; Humanos; Imino Piranoses/química; Imino Piranoses/farmacologia; Estrutura Molecular; Relação Estrutura-Atividade

Palavras-chave

Fabry's disease; Fluorosugar; G(M1)-gangliosidosis; Galactosidase inhibitor; Iminoalditol; Pharmacological chaperone

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Inibidores Enzimáticos / Imino Piranoses / Galactosidases Limite: Humans Idioma: En Revista: Carbohydr Res Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Áustria

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