Quantification of bone marrow water and lipid composition in anterior cruciate ligament-injured and osteoarthritic knees using three-dimensional magnetic resonance spectroscopic imaging.
Magn Reson Imaging
; 34(5): 632-7, 2016 Jun.
Article
em En
| MEDLINE
| ID: mdl-26723848
ABSTRACT
PURPOSE:
To quantitatively evaluate longitudinal changes in water and lipid in knee bone marrow with and without bone marrow edema-like lesions (BMELs) in subjects with acutely ruptured anterior cruciate ligaments (ACLs) or osteoarthritis (OA) using three-dimensional magnetic resonance spectroscopic imaging (3D MRSI). MATERIAL ANDMETHODS:
Ten ACL and 10 OA subjects who presented with BMEL and seven BMEL-free controls were scanned at 3T. All ACL and OA subjects had one-year follow-up scans. 3D MRSI was acquired in BMEL and adjacent bone marrow, and water content (WC) and unsaturated lipid index (UI) were calculated in each region of interest.RESULTS:
At baseline, ACL BMEL WC was significantly higher than ACL non-BMEL, OA BMEL, and control WC; ACL non-BMEL WC, ACL BMEL UI, and OA BMEL WC were significantly higher than control. ACL BMEL WC decreased significantly one year post-reconstruction; UI decreased non-significantly (p=0.09). No significant changes in OA BMEL or ACL and OA non-BMEL WC and UI were observed.CONCLUSION:
3D MRSI is a powerful method of quantitatively assessing the biochemical composition of bone marrow in OA and ACL-injured knees, which may serve as imaging markers to improve comprehension of primary and secondary OA pathology.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Medula Óssea
/
Água
/
Espectroscopia de Ressonância Magnética
/
Osteoartrite do Joelho
/
Imageamento Tridimensional
/
Lesões do Ligamento Cruzado Anterior
/
Lipídeos
Tipo de estudo:
Diagnostic_studies
/
Evaluation_studies
Limite:
Adult
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Magn Reson Imaging
Ano de publicação:
2016
Tipo de documento:
Article