FGF21 Regulates Sweet and Alcohol Preference.
Cell Metab
; 23(2): 344-9, 2016 Feb 09.
Article
em En
| MEDLINE
| ID: mdl-26724861
ABSTRACT
Fibroblast growth factor 21 (FGF21) is a hormone induced by various metabolic stresses, including ketogenic and high-carbohydrate diets, that regulates energy homeostasis. In humans, SNPs in and around the FGF21 gene have been associated with macronutrient preference, including carbohydrate, fat, and protein intake. Here we show that FGF21 administration markedly reduces sweet and alcohol preference in mice and sweet preference in cynomolgus monkeys. In mice, these effects require the FGF21 co-receptor ß-Klotho in the central nervous system and correlate with reductions in dopamine concentrations in the nucleus accumbens. Since analogs of FGF21 are currently undergoing clinical evaluation for the treatment of obesity and type 2 diabetes, our findings raise the possibility that FGF21 administration could affect nutrient preference and other reward behaviors in humans.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Paladar
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Álcoois
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Fatores de Crescimento de Fibroblastos
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Preferências Alimentares
Limite:
Animals
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Humans
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Male
Idioma:
En
Revista:
Cell Metab
Assunto da revista:
METABOLISMO
Ano de publicação:
2016
Tipo de documento:
Article
País de afiliação:
Estados Unidos