Genetic Variation in S100B Modulates Neural Processing of Visual Scenes in Han Chinese.
Cereb Cortex
; 27(2): 1326-1336, 2017 02 01.
Article
em En
| MEDLINE
| ID: mdl-26733530
ABSTRACT
Spatial navigation is a crucial ability for living. Previous animal studies have shown that the S100B gene is causally related to spatial navigation performance in mice. However, the genetic factors influencing human navigation and its neural substrates remain unclear. Here, we provided the first evidence that the S100B gene modulates neural processing of navigationally relevant scenes in humans. First, with a novel protocol, we demonstrated that the spatial pattern of S100B gene expression in postmortem brains was associated with brain activation pattern for spatial navigation in general, and for scene processing in particular. Further, in a large fMRI cohort of healthy adults of Han Chinese (N = 202), we found that S100B gene polymorphisms modulated scene selectivity in the retrosplenial cortex (RSC) and parahippocampal place area. Finally, the serum levels of S100B protein mediated the association between S100B gene polymorphism and scene selectivity in the RSC. Our study takes the first step toward understanding the neurogenetic mechanism of human spatial navigation and suggests a novel approach to discover candidate genes modulating cognitive functions.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Percepção Espacial
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Encéfalo
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Córtex Cerebral
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Giro Para-Hipocampal
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Povo Asiático
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Subunidade beta da Proteína Ligante de Cálcio S100
Tipo de estudo:
Prognostic_studies
Limite:
Adolescent
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Adult
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Female
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Humans
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Male
Idioma:
En
Revista:
Cereb Cortex
Assunto da revista:
CEREBRO
Ano de publicação:
2017
Tipo de documento:
Article