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Local admixture of amplified and diversified secreted pathogenesis determinants shapes mosaic Toxoplasma gondii genomes.
Lorenzi, Hernan; Khan, Asis; Behnke, Michael S; Namasivayam, Sivaranjani; Swapna, Lakshmipuram S; Hadjithomas, Michalis; Karamycheva, Svetlana; Pinney, Deborah; Brunk, Brian P; Ajioka, James W; Ajzenberg, Daniel; Boothroyd, John C; Boyle, Jon P; Dardé, Marie L; Diaz-Miranda, Maria A; Dubey, Jitender P; Fritz, Heather M; Gennari, Solange M; Gregory, Brian D; Kim, Kami; Saeij, Jeroen P J; Su, Chunlei; White, Michael W; Zhu, Xing-Quan; Howe, Daniel K; Rosenthal, Benjamin M; Grigg, Michael E; Parkinson, John; Liu, Liang; Kissinger, Jessica C; Roos, David S; Sibley, L David.
Afiliação
  • Lorenzi H; Department of Infectious Diseases, The J. Craig Venter Institute, 9704 Medical Center Drive, Rockville, Maryland 20850, USA.
  • Khan A; Department of Molecular Microbiology, Washington University School of Medicine, 660 S. Euclid Avenue, St Louis, Missouri 63130, USA.
  • Behnke MS; Laboratory of Parasitic Diseases, NIAID, National Institutes of Health, Bethesda, Maryland 20892, USA.
  • Namasivayam S; Department of Molecular Microbiology, Washington University School of Medicine, 660 S. Euclid Avenue, St Louis, Missouri 63130, USA.
  • Swapna LS; Pathobiological Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rougea Louisian 70803, USA.
  • Hadjithomas M; Department of Genetics, University of Georgia, Athens, Georgia 30602, USA.
  • Karamycheva S; Center for Tropical and Emerging Global Diseases, University of Georgia, Athens Georgia 30602, USA.
  • Pinney D; Program in Molecular Structure and Function, Hospital for Sick Children, Toronto, Ontario, Canada M5G 1L7.
  • Brunk BP; Departments of Biochemistry and Molecular Genetics, University of Toronto, Toronto, Ontario, Canada M5S 1A8.
  • Ajioka JW; Department of Infectious Diseases, The J. Craig Venter Institute, 9704 Medical Center Drive, Rockville, Maryland 20850, USA.
  • Ajzenberg D; Department of Infectious Diseases, The J. Craig Venter Institute, 9704 Medical Center Drive, Rockville, Maryland 20850, USA.
  • Boothroyd JC; Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
  • Boyle JP; Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
  • Dardé ML; Department of Pathology, University of Cambridge, Cambridge CB2 1QP, UK.
  • Diaz-Miranda MA; Biological Resource Center for Toxoplasma, INSERM, University Limoges, CHU Limoges, UMR_S 1094, Tropical Neuroepidemiology, Institute of Neuroepidemiology and Tropical Neurology, Limoges 87025, France.
  • Dubey JP; Department of Microbiology and Immunology, Stanford School of Medicine, Stanford, California 94305, USA.
  • Fritz HM; Department of Biological Sciences, Dietrich School of Arts and Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA.
  • Gennari SM; Biological Resource Center for Toxoplasma, INSERM, University Limoges, CHU Limoges, UMR_S 1094, Tropical Neuroepidemiology, Institute of Neuroepidemiology and Tropical Neurology, Limoges 87025, France.
  • Gregory BD; Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
  • Kim K; Animal Parasitic Diseases Laboratory, Beltsville Agricultural Research Center, Agricultural Research Service, USDA, Beltsville, Maryland 20705, USA.
  • Saeij JP; Department of Veterinary Pathology and Microbiology, Washington State University, College of Veterinary Medicine, Pullman, Washington 99164, USA.
  • Su C; Department of Preventive Veterinary Medicine and Animal Health, Faculty of Veterinary Medicine, University of São Paulo, São Paulo, SP CEP 05598-270, Brazil.
  • White MW; Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
  • Zhu XQ; Departments of Medicine, Pathology, and Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York 10461, USA.
  • Howe DK; Department of Pathology, Microbiology &Immunology, University of California, David, California 95616, USA.
  • Rosenthal BM; Department of Microbiology, University of Tennessee, Knoxville, Tennessee 37996, USA.
  • Grigg ME; Departments of Molecular Medicine and Global Health, Florida Center for Drug Discovery and Development (CDDI), University of South Florida, 3720 Spectrum Boulevard, Suite 304, Tampa, Florida 33612, USA.
  • Parkinson J; State Key Laboratory of Veterinary Etiological Biology, Key Laboratory of Veterinary Parasitology of Gansu Province, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, Gansu Province 730046, China.
  • Liu L; Department of Veterinary Science, University of Kentucky, Lexington, Kentucky 40546, USA.
  • Kissinger JC; Animal Parasitic Diseases Laboratory, Beltsville Agricultural Research Center, Agricultural Research Service, USDA, Beltsville, Maryland 20705, USA.
  • Roos DS; Laboratory of Parasitic Diseases, NIAID, National Institutes of Health, Bethesda, Maryland 20892, USA.
  • Sibley LD; Program in Molecular Structure and Function, Hospital for Sick Children, Toronto, Ontario, Canada M5G 1L7.
Nat Commun ; 7: 10147, 2016 Jan 07.
Article em En | MEDLINE | ID: mdl-26738725
ABSTRACT
Toxoplasma gondii is among the most prevalent parasites worldwide, infecting many wild and domestic animals and causing zoonotic infections in humans. T. gondii differs substantially in its broad distribution from closely related parasites that typically have narrow, specialized host ranges. To elucidate the genetic basis for these differences, we compared the genomes of 62 globally distributed T. gondii isolates to several closely related coccidian parasites. Our findings reveal that tandem amplification and diversification of secretory pathogenesis determinants is the primary feature that distinguishes the closely related genomes of these biologically diverse parasites. We further show that the unusual population structure of T. gondii is characterized by clade-specific inheritance of large conserved haploblocks that are significantly enriched in tandemly clustered secretory pathogenesis determinants. The shared inheritance of these conserved haploblocks, which show a different ancestry than the genome as a whole, may thus influence transmission, host range and pathogenicity.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Toxoplasma / Genoma de Protozoário Tipo de estudo: Etiology_studies Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Toxoplasma / Genoma de Protozoário Tipo de estudo: Etiology_studies Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Estados Unidos