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Histamine Receptor H1-Mediated Sensitization of TRPV1 Mediates Visceral Hypersensitivity and Symptoms in Patients With Irritable Bowel Syndrome.
Wouters, Mira M; Balemans, Dafne; Van Wanrooy, Sander; Dooley, James; Cibert-Goton, Vincent; Alpizar, Yeranddy A; Valdez-Morales, Eduardo E; Nasser, Yasmin; Van Veldhoven, Paul P; Vanbrabant, Winde; Van der Merwe, Schalk; Mols, Raf; Ghesquière, Bart; Cirillo, Carla; Kortekaas, Inge; Carmeliet, Peter; Peetermans, Willy E; Vermeire, Séverine; Rutgeerts, Paul; Augustijns, Patrick; Hellings, Peter W; Belmans, Ann; Vanner, Stephen; Bulmer, David C; Talavera, Karel; Vanden Berghe, Pieter; Liston, Adrian; Boeckxstaens, Guy E.
Afiliação
  • Wouters MM; Department of Clinical and Experimental Medicine, Translational Research Center for Gastrointestinal Disorders, University Hospital Leuven, KU Leuven, Leuven, Belgium.
  • Balemans D; Department of Clinical and Experimental Medicine, Translational Research Center for Gastrointestinal Disorders, University Hospital Leuven, KU Leuven, Leuven, Belgium.
  • Van Wanrooy S; Department of Clinical and Experimental Medicine, Translational Research Center for Gastrointestinal Disorders, University Hospital Leuven, KU Leuven, Leuven, Belgium.
  • Dooley J; Autoimmune Genetics Laboratory, Flemish Institute for Biotechnology (VIB) and Department of Microbiology and Immunology, KU Leuven, Leuven, Belgium.
  • Cibert-Goton V; National Centre for Bowel Research and Surgical Innovation, Centre for Neuroscience and Trauma, Blizard Institute, Bart's and the London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.
  • Alpizar YA; Department of Cellular and Molecular Medicine, Laboratory of Ion Channel Research and Transient Receptor Potential (TRP) channel Research Platform, KU Leuven, Leuven, Belgium.
  • Valdez-Morales EE; Gastrointestinal Diseases Research Unit, Kingston General Hospital, Queen's University, Kingston, Canada.
  • Nasser Y; Gastrointestinal Diseases Research Unit, Kingston General Hospital, Queen's University, Kingston, Canada.
  • Van Veldhoven PP; Department of Cellular and Molecular Medicine, Laboratory of Lipid Biochemistry and Protein-Interaction, KU Leuven, Leuven, Belgium.
  • Vanbrabant W; Department of Clinical and Experimental Medicine, Translational Research Center for Gastrointestinal Disorders, University Hospital Leuven, KU Leuven, Leuven, Belgium.
  • Van der Merwe S; Department of Clinical and Experimental Medicine, Hepatology, University Hospital Leuven, KU Leuven, Leuven, Belgium.
  • Mols R; Department of Pharmaceutical and Pharmacological Sciences, Drug Delivery and Disposition, University Hospital Leuven, KU Leuven, Leuven, Belgium.
  • Ghesquière B; Laboratory of Angiogenesis and Neurovascular Link (Vesalius Research Center), KU Leuven, Leuven, Belgium.
  • Cirillo C; Department of Clinical and Experimental Medicine, Translational Research Center for Gastrointestinal Disorders, University Hospital Leuven, KU Leuven, Leuven, Belgium.
  • Kortekaas I; Department of Microbiology and Immunology, Laboratory of Clinical Immunology, KU Leuven, Leuven, Belgium.
  • Carmeliet P; Laboratory of Angiogenesis and Neurovascular Link (Vesalius Research Center), KU Leuven, Leuven, Belgium.
  • Peetermans WE; Department of Internal Medicine, Laboratory for Clinical Infectious and Inflammatory Disorders, University Hospital Leuven, KU Leuven, Leuven, Belgium.
  • Vermeire S; Department of Clinical and Experimental Medicine, Translational Research Center for Gastrointestinal Disorders, University Hospital Leuven, KU Leuven, Leuven, Belgium.
  • Rutgeerts P; Department of Clinical and Experimental Medicine, Translational Research Center for Gastrointestinal Disorders, University Hospital Leuven, KU Leuven, Leuven, Belgium.
  • Augustijns P; Department of Pharmaceutical and Pharmacological Sciences, Drug Delivery and Disposition, University Hospital Leuven, KU Leuven, Leuven, Belgium.
  • Hellings PW; Department of Microbiology and Immunology, Laboratory of Clinical Immunology, KU Leuven, Leuven, Belgium; Department of Otorhinolaryngology, Academic Medical Center Amsterdam, Amsterdam, The Netherlands; Department of Otorhinolaryngology, University of Ghent, Ghent, Belgium.
  • Belmans A; Department of Biostatistics and Centre of Statistical Bioinformatics, KU Leuven, Leuven, Belgium.
  • Vanner S; Gastrointestinal Diseases Research Unit, Kingston General Hospital, Queen's University, Kingston, Canada.
  • Bulmer DC; National Centre for Bowel Research and Surgical Innovation, Centre for Neuroscience and Trauma, Blizard Institute, Bart's and the London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.
  • Talavera K; Department of Cellular and Molecular Medicine, Laboratory of Ion Channel Research and Transient Receptor Potential (TRP) channel Research Platform, KU Leuven, Leuven, Belgium.
  • Vanden Berghe P; Department of Clinical and Experimental Medicine, Translational Research Center for Gastrointestinal Disorders, University Hospital Leuven, KU Leuven, Leuven, Belgium.
  • Liston A; Autoimmune Genetics Laboratory, Flemish Institute for Biotechnology (VIB) and Department of Microbiology and Immunology, KU Leuven, Leuven, Belgium.
  • Boeckxstaens GE; Department of Clinical and Experimental Medicine, Translational Research Center for Gastrointestinal Disorders, University Hospital Leuven, KU Leuven, Leuven, Belgium. Electronic address: guy.boeckxstaens@med.kuleuven.be.
Gastroenterology ; 150(4): 875-87.e9, 2016 Apr.
Article em En | MEDLINE | ID: mdl-26752109
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Piperidinas / Reto / Fármacos Gastrointestinais / Butirofenonas / Receptores Histamínicos H1 / Limiar da Dor / Síndrome do Intestino Irritável / Canais de Cátion TRPV / Antagonistas dos Receptores Histamínicos H1 / Analgésicos Tipo de estudo: Clinical_trials / Diagnostic_studies País/Região como assunto: Europa Idioma: En Revista: Gastroenterology Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Bélgica
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Piperidinas / Reto / Fármacos Gastrointestinais / Butirofenonas / Receptores Histamínicos H1 / Limiar da Dor / Síndrome do Intestino Irritável / Canais de Cátion TRPV / Antagonistas dos Receptores Histamínicos H1 / Analgésicos Tipo de estudo: Clinical_trials / Diagnostic_studies País/Região como assunto: Europa Idioma: En Revista: Gastroenterology Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Bélgica