Clinical/Therapeutic Approaches for Cannabinoid Ligands in Central and Peripheral Nervous System Diseases: Mini Review.
Clin Neuropharmacol
; 39(2): 94-101, 2016.
Article
em En
| MEDLINE
| ID: mdl-26818043
ABSTRACT
OBJECTIVE:
Cannabinoids, the components of Cannabis sativa Linnaeus, interact with CB1 and CB2 receptors, which are located both in the central nervous system and in the periphery and thus may exert a widespread biological activity in the body. The main medicinal properties of cannabinoids include analgesic, anti-inflammatory, antitumor, appetite stimulation, antiemesis, and muscle relaxation effects. This mini review aims to explore existing clinical trials that investigated the use of cannabinoids in diseases affecting the nervous system.METHODS:
We reviewed recent studies of cannabinoid-based therapy for disorders affecting central and peripheral nervous system in human subjects.RESULTS:
There is evidence that cannabinoid-based drugs may effectively control some symptoms associated with nervous system dysfunction, especially various types of pain and neurologic disorders, although studies are limited.CONCLUSIONS:
The efficacy of cannabinoid drugs in the treatment of nervous system diseases should be verified in future large-scale randomized clinical trials.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Canabinoides
/
Doenças do Sistema Nervoso Periférico
/
Doenças do Sistema Nervoso
Tipo de estudo:
Clinical_trials
Limite:
Humans
Idioma:
En
Revista:
Clin Neuropharmacol
Ano de publicação:
2016
Tipo de documento:
Article
País de afiliação:
Polônia