Biosynthesis of the Metalloclusters of Nitrogenases.
Annu Rev Biochem
; 85: 455-83, 2016 Jun 02.
Article
em En
| MEDLINE
| ID: mdl-26844394
ABSTRACT
Nitrogenase is a versatile metalloenzyme that is capable of catalyzing two important reactions under ambient conditions the reduction of nitrogen (N2) to ammonia (NH3), a key step in the global nitrogen cycle; and the reduction of carbon monoxide (CO) and carbon dioxide (CO2) to hydrocarbons, two reactions useful for recycling carbon waste into carbon fuel. The molybdenum (Mo)- and vanadium (V)-nitrogenases are two homologous members of this enzyme family. Each of them contains a P-cluster and a cofactor, two high-nuclearity metalloclusters that have crucial roles in catalysis. This review summarizes the progress that has been made in elucidating the biosynthetic mechanisms of the P-cluster and cofactor species of nitrogenase, focusing on what is known about the assembly mechanisms of the two metalloclusters in Mo-nitrogenase and giving a brief account of the possible assembly schemes of their counterparts in V-nitrogenase, which are derived from the homology between the two nitrogenases.
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MEDLINE
Assunto principal:
Proteínas de Bactérias
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Azotobacter vinelandii
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Coenzimas
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Subunidades Proteicas
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Molibdênio
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Nitrogenase
Idioma:
En
Revista:
Annu Rev Biochem
Ano de publicação:
2016
Tipo de documento:
Article