Astaxanthin ameliorates prenatal LPS-exposed behavioral deficits and oxidative stress in adult offspring.
BMC Neurosci
; 17: 11, 2016 Feb 08.
Article
em En
| MEDLINE
| ID: mdl-26856812
ABSTRACT
BACKGROUND:
Prenatal maternal lipopolysaccharide (LPS) exposure leads to behavioral deficits such as depression, anxiety, and schizophrenia in the adult lives. LPS-exposure resulted in the production of cytokines and oxidative damage. On the contrary, astaxanthin is a carotenoid compound, showed neuroprotective properties via its antioxidant capacity. This study examines the effect of astaxanthin on the prenatal maternal LPS-induced postnatal behavioral deficit in mice.RESULTS:
We found that prenatal LPS-exposed mice showed extensive immobile phase in the tail suspension test, higher frequent head dipping in the hole-board test and greater hypolocomotion in the open field test. All these values were statistically significant (p < 0.05). In addition, a marked elevation of the level of lipid peroxidation, advanced protein oxidation product, nitric oxide, while a pronounced depletion of antioxidant enzymes (superoxide dismutase, catalase and glutathione) were observed in the adult offspring mice that were prenatally exposed to LPS. To the contrary, 6-weeks long treatment with astaxanthin significantly improved all behavioral deficits (p < 0.05) and diminished prenatal LPS-induced oxidative stress markers in the brain and liver.CONCLUSIONS:
Taken together, these results suggest that prenatal maternal LPS-exposure leads to behavioral deficits in the adults, while astaxanthin ameliorates the behavioral deficits presumably via its antioxidant property.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Ansiedade
/
Efeitos Tardios da Exposição Pré-Natal
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Lipopolissacarídeos
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Estresse Oxidativo
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Depressão
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Antioxidantes
Limite:
Animals
/
Pregnancy
Idioma:
En
Revista:
BMC Neurosci
Assunto da revista:
NEUROLOGIA
Ano de publicação:
2016
Tipo de documento:
Article
País de afiliação:
Bangladesh