A matter of time: study of circadian clocks and their role in inflammation.
J Leukoc Biol
; 99(4): 549-60, 2016 Apr.
Article
em En
| MEDLINE
| ID: mdl-26856993
ABSTRACT
Circadian rhythms regulate changes in physiology, allowing organisms to respond to predictable environmental demands varying over a 24 h period. A growing body of evidence supports a key role for the circadian clock in the regulation of immune functions and inflammatory responses, which influence the understanding of infections and inflammatory diseases and their treatment. A variety of experimental methods have been used to assess the complex bidirectional crosstalk between the circadian clock and inflammation. In this review, we summarize the organization of the molecular clock, experimental methods used to study circadian rhythms, and both the inflammatory and immune consequences of circadian disturbance.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Modelos Animais de Doenças
/
Relógios Circadianos
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Humans
Idioma:
En
Revista:
J Leukoc Biol
Ano de publicação:
2016
Tipo de documento:
Article