The Role of Maternal-Effect Genes in Mammalian Development: Are Mammalian Embryos Really an Exception?
Stem Cell Rev Rep
; 12(3): 276-84, 2016 Jun.
Article
em En
| MEDLINE
| ID: mdl-26892267
ABSTRACT
The essential contribution of multiple maternal factors to early mammalian development is rapidly altering the view that mammals have a unique pattern of development compared to other species. Currently, over 60 maternal-effect mutations have been described in mammalian systems, including critical determinants of pluripotency. This data, combined with the evidence for lineage bias and differential gene expression in early blastomeres, strongly suggests that mammalian development is to some extent mosaic from the four-cell stage onward.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Relações Materno-Fetais
/
Desenvolvimento Embrionário
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Embrião de Mamíferos
Limite:
Animals
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Humans
Idioma:
En
Revista:
Stem Cell Rev Rep
Ano de publicação:
2016
Tipo de documento:
Article
País de afiliação:
Estados Unidos