ER stress stimulates production of the key antimicrobial peptide, cathelicidin, by forming a previously unidentified intracellular S1P signaling complex.

Park, Kyungho; Ikushiro, Hiroko; Seo, Ho Seong; Shin, Kyong-Oh; Kim, Young Il; Kim, Jong Youl; Lee, Yong-Moon; Yano, Takato; Holleran, Walter M; Elias, Peter; Uchida, Yoshikazu

Park, Kyungho; Ikushiro, Hiroko; Seo, Ho Seong; Shin, Kyong-Oh; Kim, Young Il; Kim, Jong Youl; Lee, Yong-Moon; Yano, Takato; Holleran, Walter M; Elias, Peter; Uchida, Yoshikazu.

Afiliação

Park K; Department of Dermatology, School of Medicine, University of California, San Francisco, CA 94158; Northern California Institute for Research and Education, Veterans Affairs Medical Center, San Francisco, CA 94121;
Ikushiro H; Department of Biochemistry, Osaka Medical College, Takatsuki, Osaka 569-8686, Japan;
Seo HS; Radiation Research Division, Korea Atomic Energy Research Institute, Jeongeup 580-185, Republic of Korea;
Shin KO; College of Pharmacy, Chungbuk National University, Cheongju 361-763, Republic of Korea;
Kim YI; Department of Dermatology, School of Medicine, University of California, San Francisco, CA 94158; Northern California Institute for Research and Education, Veterans Affairs Medical Center, San Francisco, CA 94121;
Kim JY; Northern California Institute for Research and Education, Veterans Affairs Medical Center, San Francisco, CA 94121; Department of Endocrinology, School of Medicine, University of California, San Francisco, CA 94121.
Lee YM; College of Pharmacy, Chungbuk National University, Cheongju 361-763, Republic of Korea;
Yano T; Department of Biochemistry, Osaka Medical College, Takatsuki, Osaka 569-8686, Japan;
Holleran WM; Department of Dermatology, School of Medicine, University of California, San Francisco, CA 94158; Northern California Institute for Research and Education, Veterans Affairs Medical Center, San Francisco, CA 94121;
Elias P; Department of Dermatology, School of Medicine, University of California, San Francisco, CA 94158; Northern California Institute for Research and Education, Veterans Affairs Medical Center, San Francisco, CA 94121;
Uchida Y; Department of Dermatology, School of Medicine, University of California, San Francisco, CA 94158; Northern California Institute for Research and Education, Veterans Affairs Medical Center, San Francisco, CA 94121; Yoshikazu.Uchida@ucsf.edu.

Proc Natl Acad Sci U S A ; 113(10): E1334-42, 2016 Mar 08.

Article em En | MEDLINE | ID: mdl-26903652

Assuntos

Peptídeos Catiônicos Antimicrobianos/metabolismo; Estresse do Retículo Endoplasmático; Lisofosfolipídeos/metabolismo; Transdução de Sinais; Esfingosina/análogos & derivados; Animais; Peptídeos Catiônicos Antimicrobianos/genética; Western Blotting; Linhagem Celular; Linhagem Celular Tumoral; Células Cultivadas; Proteínas de Choque Térmico/metabolismo; Humanos; Queratinócitos/citologia; Queratinócitos/metabolismo; Camundongos Knockout; Microscopia de Fluorescência; NF-kappa B/metabolismo; Complexo de Proteínas Formadoras de Poros Nucleares/genética; Complexo de Proteínas Formadoras de Poros Nucleares/metabolismo; Fosfotransferases (Aceptor do Grupo Álcool)/genética; Fosfotransferases (Aceptor do Grupo Álcool)/metabolismo; Ligação Proteica; Proteínas de Ligação a RNA/genética; Proteínas de Ligação a RNA/metabolismo; Receptores de Lisoesfingolipídeo/metabolismo; Reação em Cadeia da Polimerase Via Transcriptase Reversa; Esfingosina/metabolismo; Fator 2 Associado a Receptor de TNF/genética; Fator 2 Associado a Receptor de TNF/metabolismo; Catelicidinas

Palavras-chave

ER stress; cathelicidin; heat shock protein 90; innate immunity; sphingosine-1-phosphate

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Esfingosina / Lisofosfolipídeos / Transdução de Sinais / Peptídeos Catiônicos Antimicrobianos / Estresse do Retículo Endoplasmático Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2016 Tipo de documento: Article

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