Autoimmunity Against the Heart and Cardiac Myosin in Children With Myocarditis.
J Card Fail
; 22(7): 520-8, 2016 Jul.
Article
em En
| MEDLINE
| ID: mdl-26941007
ABSTRACT
BACKGROUND:
Host autoimmune activity in myocarditis has been proposed to play a role in development of cardiac disease, but evidence of autoimmunity and relationship to outcomes have not been evaluated in pediatric myocarditis.METHODS:
We performed a multi-institutional study of children with clinical myocarditis. Newly diagnosed patients were followed for up to 12 months and previously diagnosed patients at a single follow-up for serum levels of autoantibodies to human cardiac myosin, beta-adrenergic receptors 1 and 2, muscarinic-2 receptors, and antibody-mediated protein kinase A (PKA) activation in heart cells in culture. Results were compared with those of healthy control children.RESULTS:
Both previously diagnosed patient at follow-up (P = .0061) and newly diagnosed patients at presentation (P = .0127) had elevated cardiac myosin antibodies compared with control subjects. Antibody levels were not associated with recovery status at follow-up in either group. PKA activation was higher at presentation in the newly diagnosed patients who did not recovery normal function (P = .042).CONCLUSIONS:
Children with myocarditis have evidence of autoantibodies against human cardiac myosin at diagnosis and follow-up compared with control subjects. Differences in antibody-mediated cell signaling may contribute to differences in patient outcomes, as suggested by elevated antibody-mediated PKA activation in heart cells by the serum from nonrecovered patients.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Autoanticorpos
/
Autoimunidade
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Proteínas Quinases Dependentes de AMP Cíclico
/
Miosinas Cardíacas
/
Miócitos Cardíacos
/
Miocardite
Tipo de estudo:
Clinical_trials
Limite:
Child
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Child, preschool
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Humans
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Infant
Idioma:
En
Revista:
J Card Fail
Assunto da revista:
CARDIOLOGIA
Ano de publicação:
2016
Tipo de documento:
Article