The emerging role of GATA transcription factors in development and disease.

Lentjes, Marjolein H F M; Niessen, Hanneke E C; Akiyama, Yoshimitsu; de Bruïne, Adriaan P; Melotte, Veerle; van Engeland, Manon

Lentjes, Marjolein H F M; Niessen, Hanneke E C; Akiyama, Yoshimitsu; de Bruïne, Adriaan P; Melotte, Veerle; van Engeland, Manon.

Afiliação

Lentjes MH; Department of Pathology,GROW - School for Oncology and Developmental Biology,Maastricht University Medical Center,Maastricht,The Netherlands.
Niessen HE; Department of Pathology,GROW - School for Oncology and Developmental Biology,Maastricht University Medical Center,Maastricht,The Netherlands.
Akiyama Y; Department of Molecular Oncology,Graduate School of Medicine and Dentistry,Tokyo Medical and Dental University,Tokyo,Japan.
de Bruïne AP; Department of Pathology,GROW - School for Oncology and Developmental Biology,Maastricht University Medical Center,Maastricht,The Netherlands.
Melotte V; Department of Pathology,GROW - School for Oncology and Developmental Biology,Maastricht University Medical Center,Maastricht,The Netherlands.
van Engeland M; Department of Pathology,GROW - School for Oncology and Developmental Biology,Maastricht University Medical Center,Maastricht,The Netherlands.

Expert Rev Mol Med ; 18: e3, 2016 Mar 08.

Article em En | MEDLINE | ID: mdl-26953528

ABSTRACT

ABSTRACT

The GATA family of transcription factors consists of six proteins (GATA1-6) which are involved in a variety of physiological and pathological processes. GATA1/2/3 are required for differentiation of mesoderm and ectoderm-derived tissues, including the haematopoietic and central nervous system. GATA4/5/6 are implicated in development and differentiation of endoderm- and mesoderm-derived tissues such as induction of differentiation of embryonic stem cells, cardiovascular embryogenesis and guidance of epithelial cell differentiation in the adult.

Assuntos

Endoderma/metabolismo; Fatores de Transcrição GATA/genética; Regulação da Expressão Gênica no Desenvolvimento; Mesoderma/metabolismo; Neoplasias/genética; Animais; Sistema Cardiovascular/crescimento & desenvolvimento; Sistema Cardiovascular/metabolismo; Diferenciação Celular; Sistema Nervoso Central/crescimento & desenvolvimento; Sistema Nervoso Central/metabolismo; Células-Tronco Embrionárias/citologia; Células-Tronco Embrionárias/metabolismo; Endoderma/citologia; Endoderma/crescimento & desenvolvimento; Células Epiteliais/citologia; Células Epiteliais/metabolismo; Fatores de Transcrição GATA/metabolismo; Sistema Hematopoético/crescimento & desenvolvimento; Sistema Hematopoético/metabolismo; Humanos; Mesoderma/citologia; Mesoderma/crescimento & desenvolvimento; Mutação; Neoplasias/metabolismo; Neoplasias/patologia; Porfiria Eritropoética/genética; Porfiria Eritropoética/metabolismo; Porfiria Eritropoética/patologia; Transdução de Sinais

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Regulação da Expressão Gênica no Desenvolvimento / Endoderma / Fatores de Transcrição GATA / Mesoderma / Neoplasias Limite: Animals / Humans Idioma: En Revista: Expert Rev Mol Med Assunto da revista: BIOLOGIA MOLECULAR Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Holanda

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