The 3D Genome as Moderator of Chromosomal Communication.
Cell
; 164(6): 1110-1121, 2016 Mar 10.
Article
em En
| MEDLINE
| ID: mdl-26967279
ABSTRACT
Proper expression of genes requires communication with their regulatory elements that can be located elsewhere along the chromosome. The physics of chromatin fibers imposes a range of constraints on such communication. The molecular and biophysical mechanisms by which chromosomal communication is established, or prevented, have become a topic of intense study, and important roles for the spatial organization of chromosomes are being discovered. Here we present a view of the interphase 3D genome characterized by extensive physical compartmentalization and insulation on the one hand and facilitated long-range interactions on the other. We propose the existence of topological machines dedicated to set up and to exploit a 3D genome organization to both promote and censor communication along and between chromosomes.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Cromossomos
/
Genoma
Limite:
Animals
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Female
/
Humans
Idioma:
En
Revista:
Cell
Ano de publicação:
2016
Tipo de documento:
Article