Heparan Sulfate in the Developing, Healthy, and Injured Lung.
Am J Respir Cell Mol Biol
; 55(1): 5-11, 2016 07.
Article
em En
| MEDLINE
| ID: mdl-26982577
ABSTRACT
Remarkable progress has been achieved in understanding the regulation of gene expression and protein translation, and how aberrancies in these template-driven processes contribute to disease pathogenesis. However, much of cellular physiology is controlled by non-DNA, nonprotein mediators, such as glycans. The focus of this Translational Review is to highlight the importance of a specific glycan polymer-the glycosaminoglycan heparan sulfate (HS)-on lung health and disease. We demonstrate how HS contributes to lung physiology and pathophysiology via its actions as both a structural constituent of the lung parenchyma as well as a regulator of cellular signaling. By highlighting current uncertainties in HS biology, we identify opportunities for future high-impact pulmonary and critical care translational investigations.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Lesão Pulmonar
/
Heparitina Sulfato
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Pulmão
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Am J Respir Cell Mol Biol
Assunto da revista:
BIOLOGIA MOLECULAR
Ano de publicação:
2016
Tipo de documento:
Article