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Design, synthesis and structure activity relationship of potent pan-PIM kinase inhibitors derived from the pyridyl carboxamide scaffold.
Nishiguchi, Gisele A; Burger, Matthew T; Han, Wooseok; Lan, Jiong; Atallah, Gordana; Tamez, Victoriano; Lindvall, Mika; Bellamacina, Cornelia; Garcia, Pablo; Feucht, Paul; Zavorotinskaya, Tatiana; Dai, Yumin; Wong, Kent.
Afiliação
  • Nishiguchi GA; Global Discovery Chemistry, Novartis Institutes for Biomedical Research, 4560 Horton Street, Emeryville, CA 94608, United States. Electronic address: gisele.nishiguchi@novartis.com.
  • Burger MT; Global Discovery Chemistry, Novartis Institutes for Biomedical Research, 4560 Horton Street, Emeryville, CA 94608, United States.
  • Han W; Global Discovery Chemistry, Novartis Institutes for Biomedical Research, 4560 Horton Street, Emeryville, CA 94608, United States.
  • Lan J; Global Discovery Chemistry, Novartis Institutes for Biomedical Research, 4560 Horton Street, Emeryville, CA 94608, United States.
  • Atallah G; Global Discovery Chemistry, Novartis Institutes for Biomedical Research, 4560 Horton Street, Emeryville, CA 94608, United States.
  • Tamez V; Global Discovery Chemistry, Novartis Institutes for Biomedical Research, 4560 Horton Street, Emeryville, CA 94608, United States.
  • Lindvall M; Global Discovery Chemistry, Novartis Institutes for Biomedical Research, 4560 Horton Street, Emeryville, CA 94608, United States.
  • Bellamacina C; Global Discovery Chemistry, Novartis Institutes for Biomedical Research, 4560 Horton Street, Emeryville, CA 94608, United States.
  • Garcia P; Oncology, Novartis Institutes for Biomedical Research, 4560 Horton Street, Emeryville, CA 94608, United States.
  • Feucht P; Oncology, Novartis Institutes for Biomedical Research, 4560 Horton Street, Emeryville, CA 94608, United States.
  • Zavorotinskaya T; Oncology, Novartis Institutes for Biomedical Research, 4560 Horton Street, Emeryville, CA 94608, United States.
  • Dai Y; Oncology, Novartis Institutes for Biomedical Research, 4560 Horton Street, Emeryville, CA 94608, United States.
  • Wong K; Global Discovery Chemistry, Novartis Institutes for Biomedical Research, 4560 Horton Street, Emeryville, CA 94608, United States.
Bioorg Med Chem Lett ; 26(9): 2328-32, 2016 May 01.
Article em En | MEDLINE | ID: mdl-26995528
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Desenho de Fármacos / Inibidores de Proteínas Quinases / Proteínas Proto-Oncogênicas c-pim-1 / Amidas Idioma: En Revista: Bioorg Med Chem Lett Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2016 Tipo de documento: Article
Texto completo
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Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Desenho de Fármacos / Inibidores de Proteínas Quinases / Proteínas Proto-Oncogênicas c-pim-1 / Amidas Idioma: En Revista: Bioorg Med Chem Lett Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2016 Tipo de documento: Article