The Balancing Act of Ribonucleotides in DNA.
Trends Biochem Sci
; 41(5): 434-445, 2016 05.
Article
em En
| MEDLINE
| ID: mdl-26996833
ABSTRACT
The abundance of ribonucleotides in DNA remained undetected until recently because they are efficiently removed by the ribonucleotide excision repair (RER) pathway, a process similar to Okazaki fragment (OF) processing after incision by Ribonuclease H2 (RNase H2). All DNA polymerases incorporate ribonucleotides during DNA synthesis. How many, when, and why they are incorporated has been the focus of intense work during recent years by many labs. In this review, we discuss recent advances in ribonucleotide incorporation by eukaryotic DNA polymerases that suggest an evolutionarily conserved role for ribonucleotides in DNA. We also review the data that indicate that removal of ribonucleotides has an important role in maintaining genome stability.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Ribonucleotídeos
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DNA
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Ribonuclease H
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Doenças Autoimunes do Sistema Nervoso
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Reparo do DNA
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Lúpus Eritematoso Sistêmico
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Malformações do Sistema Nervoso
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Trends Biochem Sci
Ano de publicação:
2016
Tipo de documento:
Article
País de afiliação:
Estados Unidos