Anti-inflammatory Effect of Mesenchymal Stromal Cell Transplantation and Quercetin Treatment in a Rat Model of Experimental Cerebral Ischemia.
Cell Mol Neurobiol
; 36(7): 1023-34, 2016 Oct.
Article
em En
| MEDLINE
| ID: mdl-27008429
ABSTRACT
Here, we have investigated the synergistic effect of quercetin administration and transplantation of human umbilical cord mesenchymal stromal cells (HUMSCs) following middle cerebral artery occlusion in rat. Combining quercetin treatment with delayed transplantation of HUMSCs after local cerebral ischemia significantly (i) improved neurological functional recovery; (ii) reduced proinflammatory cytokines (interleukin(IL)-1ß and IL-6), increased anti-inflammatory cytokines (IL-4, IL-10, and transforming growth factor-ß1), and reduced ED-1 positive areas; (iii) inhibited cell apoptosis (caspase-3 expression); and (iv) improved the survival rate of HUMSCs in the injury site. Altogether, our results demonstrate that combined HUMSC transplantation and quercetin treatment is a potential strategy for reducing secondary damage and promoting functional recovery following cerebral ischemia.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Quercetina
/
Cordão Umbilical
/
Isquemia Encefálica
/
Citocinas
/
Transplante de Células-Tronco Mesenquimais
/
Células-Tronco Mesenquimais
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Female
/
Humans
Idioma:
En
Revista:
Cell Mol Neurobiol
Ano de publicação:
2016
Tipo de documento:
Article
País de afiliação:
China