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Heme interacts with histidine- and tyrosine-based protein motifs and inhibits enzymatic activity of chloramphenicol acetyltransferase from Escherichia coli.
Brewitz, Hans Henning; Goradia, Nishit; Schubert, Erik; Galler, Kerstin; Kühl, Toni; Syllwasschy, Benjamin; Popp, Jürgen; Neugebauer, Ute; Hagelueken, Gregor; Schiemann, Olav; Ohlenschläger, Oliver; Imhof, Diana.
Afiliação
  • Brewitz HH; Pharmaceutical Chemistry I, Institute of Pharmacy, University of Bonn, 53119 Bonn, Germany.
  • Goradia N; Leibniz Institute on Aging, Fritz Lipmann Institute, 07745 Jena, Germany.
  • Schubert E; Institute of Physical and Theoretical Chemistry, University of Bonn, 53115 Bonn, Germany.
  • Galler K; Center for Sepsis Control and Care (CSCC), Jena University Hospital, 07747 Jena, Germany; Leibniz Institute of Photonic Technology, 07745 Jena, Germany.
  • Kühl T; Centre National de la Recherche Scientifique (CNRS), Bioénergetique et Ingenierie des Protéines, UMR 7281, 13009 Marseille, France.
  • Syllwasschy B; Pharmaceutical Chemistry I, Institute of Pharmacy, University of Bonn, 53119 Bonn, Germany.
  • Popp J; Center for Sepsis Control and Care (CSCC), Jena University Hospital, 07747 Jena, Germany; Leibniz Institute of Photonic Technology, 07745 Jena, Germany; Institute of Physical Chemistry and Abbe Center of Photonics, Friedrich Schiller University Jena, 07743 Jena, Germany.
  • Neugebauer U; Center for Sepsis Control and Care (CSCC), Jena University Hospital, 07747 Jena, Germany; Leibniz Institute of Photonic Technology, 07745 Jena, Germany.
  • Hagelueken G; Institute of Physical and Theoretical Chemistry, University of Bonn, 53115 Bonn, Germany.
  • Schiemann O; Institute of Physical and Theoretical Chemistry, University of Bonn, 53115 Bonn, Germany.
  • Ohlenschläger O; Leibniz Institute on Aging, Fritz Lipmann Institute, 07745 Jena, Germany. Electronic address: oliver.ohlenschlaeger@leibniz-fli.de.
  • Imhof D; Pharmaceutical Chemistry I, Institute of Pharmacy, University of Bonn, 53119 Bonn, Germany. Electronic address: dimhof@uni-bonn.de.
Biochim Biophys Acta ; 1860(6): 1343-53, 2016 Jun.
Article em En | MEDLINE | ID: mdl-27015758
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Cloranfenicol O-Acetiltransferase / Inibidores Enzimáticos / Escherichia coli / Heme Tipo de estudo: Prognostic_studies Idioma: En Revista: Biochim Biophys Acta Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Alemanha
Texto completo
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PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Cloranfenicol O-Acetiltransferase / Inibidores Enzimáticos / Escherichia coli / Heme Tipo de estudo: Prognostic_studies Idioma: En Revista: Biochim Biophys Acta Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Alemanha