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Resection of colorectal liver metastases and extra-hepatic disease: a systematic review and proportional meta-analysis of survival outcomes.
Hadden, William J; de Reuver, Philip R; Brown, Kai; Mittal, Anubhav; Samra, Jaswinder S; Hugh, Thomas J.
Afiliação
  • Hadden WJ; Northern Clinical School, University of Sydney, Sydney, New South Wales, Australia.
  • de Reuver PR; Upper GI Surgical Unit, Royal North Shore Hospital and North Shore Private Hospital, Sydney, New South Wales, Australia.
  • Brown K; Northern Clinical School, University of Sydney, Sydney, New South Wales, Australia; Upper GI Surgical Unit, Royal North Shore Hospital and North Shore Private Hospital, Sydney, New South Wales, Australia.
  • Mittal A; Northern Clinical School, University of Sydney, Sydney, New South Wales, Australia; Upper GI Surgical Unit, Royal North Shore Hospital and North Shore Private Hospital, Sydney, New South Wales, Australia.
  • Samra JS; Northern Clinical School, University of Sydney, Sydney, New South Wales, Australia; Upper GI Surgical Unit, Royal North Shore Hospital and North Shore Private Hospital, Sydney, New South Wales, Australia.
  • Hugh TJ; Northern Clinical School, University of Sydney, Sydney, New South Wales, Australia; Upper GI Surgical Unit, Royal North Shore Hospital and North Shore Private Hospital, Sydney, New South Wales, Australia. Electronic address: tom.hugh@sydney.edu.au.
HPB (Oxford) ; 18(3): 209-20, 2016 Mar.
Article em En | MEDLINE | ID: mdl-27017160
ABSTRACT

BACKGROUND:

Colorectal cancer (CRC) accounts for 9.7% of all cancers with 1.4 million new cases diagnosed each year. 19-31% of CRC patients develop colorectal liver metastases (CRLM), and 23-38% develop extra-hepatic disease (EHD). The aim of this systematic review was to determine overall survival (OS) in patients resected for CRLM and known EHD.

METHODS:

A systematic review was undertaken to identify studies reporting OS after resection for CRLM in the presence of EHD. Proportional meta-analyses and relative risk of death before five years were assessed between patient groups.

RESULTS:

A total of 15,144 patients with CRLM (2308 with EHD) from 52 studies were included. Three and 5-year OS were 58% and 26% for lung, 37% and 17% for peritoneum, and 35% and 15% for lymph nodes, respectively. The combined relative risk of death by five years was 1.49 (95% CI = 1.34-1.66) for lung, 1.59 (95% CI = 1.16-2.17) for peritoneal and 1.70 (95% CI = 1.57-1.84) for lymph node EHD, in favour of resection in the absence of EHD.

CONCLUSION:

This review supports attempts at R0 resection in selected patients and rejects the notion that EHD is an absolute contraindication to resection.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Colorretais / Hepatectomia / Neoplasias Hepáticas Tipo de estudo: Etiology_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Limite: Humans Idioma: En Revista: HPB (Oxford) Assunto da revista: GASTROENTEROLOGIA Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Austrália
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Colorretais / Hepatectomia / Neoplasias Hepáticas Tipo de estudo: Etiology_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Limite: Humans Idioma: En Revista: HPB (Oxford) Assunto da revista: GASTROENTEROLOGIA Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Austrália